ArticleNeuropsychiatric disease and treatment2025
Emerging Implications of Serum Resolvin D2 as a Biochemical Marker for Severity Assessment and Prognosis Prediction Following Moderate-Severe Traumatic Brain Injury: A Prospective Cohort Study.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Immunological response and tissue loss in a rodent model of chronic traumatic brain injury treated with resolvin.Journal of inflammation (London, England) · 2025Article
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8 authors.
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Abstract
Background: Resolvin D2 (RvD2), which exhibits anti-inflammatory properties, is neuroprotective. This study aimed to ascertain the potential of serum RvD2 level as a prognostic predictor of moderate-to-severe traumatic brain injury (msTBI). Methods: In this prospective cohort study, serum RvD2 levels were measured in 136 patients with msTBI and 100 healthy controls. The severity scoring systems encompassed the Rotterdam computed tomography classification and Glasgow Coma Scale (GCS). Post-trauma six-month Glasgow outcome scale (GOS) was deemed an outcome indicator, with GOS scores below 4 indicating poor prognosis. Sequential univariate and multivariate analyses were used to determine the correlative factors of changeable serum RvD2 levels and the predictors of adverse prognosis. Results: Patients displayed a marked decline in serum RvD2 levels compared to controls (median, 95.2 versus 252.8 pg/mL; P<0.001). Serum RvD2 levels were independently correlated with GCS scores (beta, 8.989; 95% confidence interval (CI), 3.678-14.280; P=0.001) and Rotterdam scores (beta, -14.676; 95% CI, -25.885--3.468; P=0.011), and were independently associated with continuous GOS scores (beta, 0.004; 95% CI, 0.002-0.007; P=0.003), ordinal GOS scores (odds ratio, 1.008; 95% CI, 1.002-1.015; P=0.015), and poor prognosis (odds ratio, 0.991; 95% CI, 0.983-0.999; P=0.037) at the six-month mark. A linear correlation was observed between serum RvD2 levels and the likelihood of poor prognosis (P for nonlinear = 0.090). Serum RvD2 levels exhibited strong discrimination efficiency for the probability of poor prognosis (P<0.001), with similar ability as Rotterdam scores (P=0.337) and GCS scores (P=0.300). The integrative model encompassing serum RvD2, Rotterdam scores and GCS scores performed well using a series of statistical methods. Conclusion: A significant decrease in serum RvD2 levels after msTBI may accurately indicate trauma severity and efficiently distinguish the possibility of poor neurological outcomes in msTBI, signifying that serum RvD2 may be of clinical significance in the prognostic prediction of TBI.
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