Evidence map›Paper›PMID 39810790›Full record

ArticleKidney international reports2025

Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study.

Tim J Knobbe, Gijs M M Lenis, Dirk A J van der Vossen, Jory Wentink, Daan Kremer, Evelien E Quint, Antonio W Gomes-Neto, Robin P F Dullaart, Robert A Pol, Stefan P Berger and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tim J KnobbeDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Gijs M M LenisDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dirk A J van der VossenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jory WentinkDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Daan KremerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Evelien E QuintDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Antonio W Gomes-NetoDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Robin P F DullaartDepartment of endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Robert A PolDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stefan P BergerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Casper F M FranssenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stephan J L BakkerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Adrian PostDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
TransplantLines Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Muscles are crucial for daily activities, and kidney transplant recipients (KTRs) often have reduced muscle mass and strength. We aimed to investigate the potential relationship of muscle mass and strength with physical health-related quality of life (HRQoL) in KTRs. Methods: Data from the TransplantLines Biobank and Cohort Studies were used. Muscle mass was assessed using appendicular skeletal muscle mass index (ASMI) and 24-hour urinary creatinine excretion rate index (CERI). Muscle strength was assessed by handgrip strength index (HGSI). HRQoL was measured using Short Form 36 physical component score (PCS). Results: We included 751 KTRs (61% male; mean age, 56 ± 13 years, median of 3 years post-transplant). Ordinary least squares regression analyses demonstrated that lower ASMI, CERI, and HGSI were all nonlinearly associated with lower PCS, independent of potential confounders and each other. Below median values, ASMI, CERI, and HGSI were each associated with PCS; whereas above median values, associations were less pronounced. Compared to the 50th percentile, a decrease to the 10th percentile was associated with a change in PCS of -4.8% for ASMI ( Conclusion: Low muscle mass and strength are potentially modifiable risk factors for impaired physical HRQoL in KTRs. The nonlinear associations suggest that KTRs with low muscle mass or strength may particularly benefit from (p)rehabilitation interventions to improve HRQoL.

Indexed as

kidney transplantationmuscle weaknesspatient-reported outcome measuresphysical fitnesssarcopenia

Identifiers

PMID39810790
PMCPMC11725826

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