Evidence map›Paper›PMID 39810280›Full record

ArticlePilot and feasibility studies2025

Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment.

Juliana V Costa, Alexander R Lucas, Shannon L Mihalko, Peter H Brubaker, Alexandra Marshall, Brianna Leitzelar, Brianna R Wolle, Samuel Norton, R Lee Franco, Jeremy Via and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01719562 (Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment - An Addendum to NIH R01CA167821 "Early Imaging Detection of Cardiovascular Injury After Cancer"), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01719562 nacompletednot on this map

Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment - An Addendum to NIH R01CA167821 "Early Imaging Detection of Cardiovascular Injury After Cancer"

TypeinterventionalSponsorWake Forest University Health SciencesRan2013 to 2022Enrolled28ConditionsCardiac Toxicity, Malignant Neoplasm, Breast CancerArmsMagnetic resonance imaging, Physical Activity, Healthy Living, Cardiopulmonary Exercise Testing (CPET), Questionnaire Administration
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juliana V Costa *Department of Health and Exercise Science, Wake Forest University, Worrell Professional Center, Winston-Salem, NC, 27109, USA.
Alexander R Lucas *Department of Internal Medicine - Cardiology, Virginia Commonwealth University, West Hospital 8th Floor, North Wing, Richmond, VA, 23298, USA.
Shannon L MihalkoDepartment of Health and Exercise Science, Wake Forest University, Worrell Professional Center, Winston-Salem, NC, 27109, USA.
Peter H BrubakerDepartment of Health and Exercise Science, Wake Forest University, Worrell Professional Center, Winston-Salem, NC, 27109, USA.
Alexandra MarshallDepartment of Internal Medicine - Cardiology, Virginia Commonwealth University, West Hospital 8th Floor, North Wing, Richmond, VA, 23298, USA.
Brianna LeitzelarDepartment of Social Science and Health Policy, Wake Forest University School of Medicine, 1 Medical Center Blvd, Winston-Salem, Winston-Salem, NC, 25157, USA.
Brianna R WolleDepartment of Health and Exercise Science, Wake Forest University, Worrell Professional Center, Winston-Salem, NC, 27109, USA.
Samuel NortonDepartment of Health and Exercise Science, Wake Forest University, Worrell Professional Center, Winston-Salem, NC, 27109, USA.
R Lee FrancoDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, 813 W Franklin St, Richmond, VA, 23284, USA.
Jeremy ViaDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, 813 W Franklin St, Richmond, VA, 23284, USA.
Victor YazbeckMassey Cancer Center, Virginia Commonwealth University, 401 College St, Box 980035, Richmond, VA, 23298, USA.
Rakhee VaidyaDepartment of Internal Medicine (Section On Oncology), Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC, USA.
Mary Beth SeegarsDepartment of Internal Medicine (Section On Oncology), Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC, USA.
Ralph D'AgostinoDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lynne WagnerDepartment Of Health Policy and Management, University of North Carolina Gillings School of Global Public Health, 170 Rosenau Hall, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.
W Gregory HundleyDepartment of Internal Medicine - Cardiology, Virginia Commonwealth University, West Hospital 8th Floor, North Wing, Richmond, VA, 23298, USA. greg.hundley@vcuhealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy.

methodsPatients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)) were randomized into the PAI or healthy living intervention (HLI) control (2:1). Feasibility was assessed by examining accrual, adherence, and retention rates. Participants completed assessments of exercise capacity (VO

resultsOne hundred and forty-five individuals were screened with 23 of 84 eligible patients agreeing to participate (27%). Three participants withdrew before baseline testing. Out of the 20 participants randomized to the PAI (n = 13) and HLI groups (n = 7), 18 completed the intervention resulting in an overall retention rate of 78%. The adherence rates to the PAI and HLI were 85% and 87%, respectively. One non-serious adverse event was registered. VO

conclusionsImplementing a tailored PAI in adults with lymphoma during active treatment is feasible, was well received by participants and shows preliminary efficacy for limiting a decline in function during treatment. Potential Implications for Cancer Survivors: Physical activity may be beneficial for improving exercise capacity and health-related quality of life in patients undergoing chemotherapy.

trial registration#NCT01719562 ClinicalTrials.gov. Registered July 2, 2019-retrospectively registered.

Indexed as

CardiotoxicityExercise capacityHealth-related quality of lifeLymphomaPhysical activityRandomized controlled pilot trial

Identifiers

PMID39810280
PMCPMC11731389

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.