ArticleCell communication and signaling : CCS2025
Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP
Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Effects of Disrupting CaMarine biotechnology (New York, N.Y.) · 2026Article
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3 authors.
Funding
Abstract
backgroundBok is a poorly characterized Bcl-2 protein family member with roles yet to be clearly defined. It is clear, however, that Bok binds strongly to inositol 1,4,5-trisphosphate (IP
methodsBok Ser-8 phosphorylation was characterized using purified proteins, G-protein coupled receptor agonists that increase cAMP levels in intact cells, mass spectrometry, and immunoreactivity changes. Also, using mammalian cells that exclusively or predominately express IP
resultsOur results confirm that Ser-8 of Bok is phosphorylated by cAMP-dependent protein kinase, and remarkably that phosphorylation can be detected with Bok specific antibodies. Also, we find that Bok has suppressive effects on IP
conclusionsFor the first time, Bok was shown to directly suppress IP
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