ArticleJournal of translational medicine2025
Metabolic and inflammatory status in prepuberty and early adulthood for individuals with a history of extrauterine growth restriction: a cohort study.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPerinatal growth and nutrition have been shown to be determinants in the programming of different tissues, such as adipose tissue, predisposing individuals to metabolic alterations later in life. Previous studies have documented an increased risk of metabolic disturbances and low-grade inflammation in prepubertal children with a history of extrauterine growth restriction (EUGR). The aim of this study was to evaluate possible alterations resulting from impaired growth during early childhood and their impact on young adult health.
methodsThis is a longitudinal, descriptive and analytical study of a cohort with a history of EUGR recruited at prepubertal age and followed up for 10 years until the end of puberty. Anthropometric measurements, blood pressure, biochemical parameters related to lipid and carbohydrate metabolism and plasma adipokines and cytokines were analyzed.
resultsCompared with prepubertal children, young adults EUGR presented increased abdominal circumference percentiles. Moreover, insulin levels and the homeostatic model assessment for insulin resistance (HOMA-IR) index were higher in young adults, with a considerable proportion of participants (22%) becoming insulin-resistant after pubertal development. In contrast, arterial hypertension was observed in 36% of prepubertal children compared with 18% of postpubertal young adults. Lipid values were within normal ranges without differences. Adiponectin and leptin remained at similar levels in adulthood, with a decrease in resistin.
conclusionIndividuals with a history of EUGR have increased metabolic risk in adulthood, which emphasizes the importance of clinical follow-up from childhood to prevent the development of further future associated diseases.
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