Evidence map›Paper›PMID 39810178›Full record

Observational studyBMC medical genomics2025

Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment.

Julie Vinkel, Alfonso Buil, Ole Hyldegaard

Registry-linked trialAbstract readObservational StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC medical genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01790698 (Improving Outcome of Necrotizing Fasciitis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01790698 completednot on this map

Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures That Dictate Severity of Tissue Infection

Typeobservational_patient_registrySponsorKarolinska InstitutetRan2013 to 2018Enrolled409ConditionsSoft Tissue Infections, Necrotizing Fasciitis, Necrotizing Soft Tissue Infections
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julie VinkelDepartment of Anaesthesiology, Centre of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 6, Copenhagen, 2100, Denmark. julie.vinkel.clausen@regionh.dk.
Alfonso BuilInstitute for Biological Psychiatry, Mental Health Centre Sct. Hans, Roskilde, Denmark.
Ole HyldegaardDepartment of Anaesthesiology, Centre of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 6, Copenhagen, 2100, Denmark.

Funding

Horizon 2020 Framework Programme 8113-00009BInnovationsfonden 8113-00009BNordForsk 8114-00005B
6 · The paper itself

Abstract

backgroundSepsis and shock are common complications of necrotising soft tissue infections (NSTI). Sepsis encompasses different endotypes that are associated with specific immune responses. Hyperbaric oxygen (HBO

methodsAn observational cohort study examining 83 NSTI patients treated with HBO

resultsWe identified differences in gene expression profiles at follow-up between HBO

conclusionThe global gene expression pattern in blood changed in response to HBO

trial registrationBiological material was collected during the INFECT study, registered at ClinicalTrials.gov (NCT01790698) 04/02/2013.

Indexed as

Hyperbaric OxygenationSepsisSoft Tissue InfectionsTranscriptomeAdultAgedCohort StudiesFemaleGene Expression ProfilingHumansMaleMiddle AgedHyperbaric oxygen treatmentNecrotising soft tissue infectionSepsisSepsis-endotypesTranscriptomics

Identifiers

PMID39810178
PMCPMC11734498

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.