Evidence map›Paper›PMID 39810098›Full record

SynthesisBMC pregnancy and childbirth2025

Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt.

Ahmed Azzam, Heba Khaled, Alrefaey K Alrefaey, Amar Basil, Sarah Ibrahim, Mohamed S Elsayed, Muhammad Khattab, Nashwa Nabil, Esraa Abdalwanees, Hala Waheed Abdel Halim

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Iron deficiency with and without anemia in pregnancy: A scoping review of prevalence and perinatal impact.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed AzzamDepartment of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Heba KhaledDepartment of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Alrefaey K AlrefaeyDepartment of Anesthesia, Intensive Care, and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Amar BasilIntern, Bashir Hospital, Amman, Jordan.
Sarah IbrahimPrimary Care Physician, Urban Medical Center, Cairo, Egypt.
Mohamed S ElsayedPharmacist, Mansoura University Children's Hospital, Mansoura, Egypt.
Muhammad KhattabSpecialty Doctor in Surgery, Yeovil District Hospital, NHS Foundation Trust, Somerset, UK.
Nashwa NabilDepartment of Community, Environmental and Occupational Medicine, Faculty of Medicine, Benha University, Benha, Egypt.
Esraa AbdalwaneesPediatric Specialist, Ain Alkhaleej Hospital, Al Ain City, Abu Dhabi, UAE.
Hala Waheed Abdel HalimDepartment of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. halawahed.19@azhar.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe WHO considers anemia in pregnancy a severe public health issue when prevalence surpasses 40%. In response, we conducted a systematic review and meta-analysis to examine anemia among pregnant women in Egypt, focusing on its prevalence, determinants, and associated complications.

methodsWe conducted a systematic literature search for studies published between January 1, 2010, and August 18, 2024, to identify studies from Egypt reporting on anemia in pregnant women, including its prevalence, associated determinants, and complications. A meta-analysis was conducted using a random-effects model to estimate pooled prevalence, odds ratios (OR), and standardized mean differences (SMD). Sensitivity analyses and publication bias were performed. All statistical analyses were conducted using R software.

resultsEighteen studies met the eligibility criteria with a total sample size of 14,548. The overall prevalence of anemia among pregnant women was 49% (95% CI: 42-57), with no significant difference between Upper and Lower Egypt (P = 0.66). The sensitivity analysis demonstrated the absence of influential outliers and Egger's test indicated no evidence of publication bias (P = 0.17). Anemia prevalence was significantly higher in the third trimester (65%) compared to the second trimester (47%) (P = 0.03). Among anemic pregnant women, most cases were mild (47%) and moderate (47%). The determinants of anemia among pregnant women included being over 30 years old (OR: 1.95), residing in rural areas (OR: 1.76), illiteracy (OR: 1.93), birth spacing < 2 years (OR: 2.04), lack of iron supplementation (OR: 2.59), presence of intestinal parasites (OR: 1.38), antenatal visits < 5 (OR: 5.27), multiparity, and low income, all with statistical significance (p < 0.05). Regarding dietary determinants, a low intake of meat, vegetables, fruits, and high tea consumption was consistently associated with a higher risk of anemia. For neonatal complications, infants born to anemic mothers had significantly lower Apgar scores, gestational ages, and birth weights (P < 0.05), with birth weight being the most adversely impacted (SMD = -1.3).

conclusionsThis meta-analysis shows 49% anemia prevalence in pregnant Egyptian women, indicating severe health concern. The findings highlight the urgent need for targeted interventions aimed at addressing the key determinants identified in this study.

Indexed as

AnemiaPregnancy Complications, HematologicEgyptFemaleHumansPregnancyPrevalenceRisk FactorsAnemiaApgarComplicationsDeterminantsEgyptMeta-analysisPregnancy

Identifiers

PMID39810098
PMCPMC11731563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.