Evidence map›Paper›PMID 39810072›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2025

Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.

Aleksandra Ivanovic, Jeffrey Tao Cheng, Margaux Schmeltz, Wilhelm Wimmer, Christian M Schlepuetz, Aaron K Remenschneider, Anne Bonnin, Lukas Anschuetz

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aleksandra IvanovicDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Freiburgstrasse, Bern, Switzerland. aleksandra.ivanovic@unibe.ch.ORCID http://orcid.org/0000-0002-1322-3794
Jeffrey Tao ChengEaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA.
Margaux SchmeltzSwiss Light Source, Paul Scherrer Institut, Villigen PSI, Switzerland.
Wilhelm WimmerDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Freiburgstrasse, Bern, Switzerland.
Christian M SchlepuetzSwiss Light Source, Paul Scherrer Institut, Villigen PSI, Switzerland.
Aaron K RemenschneiderEaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA.
Anne BonninSwiss Light Source, Paul Scherrer Institut, Villigen PSI, Switzerland.
Lukas AnschuetzDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Freiburgstrasse, Bern, Switzerland.

Funding

Middle Ear Nonlinearity in High Intensity Sound: Impact on Hearing Damage and ProtectionR01DC016079 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Jeffrey Tao Cheng · 2017 to 2026
$4.1M
NIDCD NIH HHS R01 DC016079NIH HHS NIH R01 DC016079Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030\_192660
6 · The paper itself

Abstract

purposeThere are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).

methodsWe examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512 Hz, stimulated at 110 dB and 120 dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method.

resultsThe normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5-10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.

conclusionIn conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear's biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.

Indexed as

Ear, MiddleLaser-Doppler FlowmetryX-Ray MicrotomographyBiomechanical PhenomenaFemaleHumansMaleSynchrotronsTemporal BoneVibrationDynamic synchrotron-based X-ray microtomographyLaser Doppler vibrometryMiddle earPhase-contrast

Identifiers

PMID39810072
PMCPMC11861830

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.