Evidence map›Paper›PMID 39810069›Full record

ArticleMolecular imaging and biology2025

2-[

Juan A Azcona, Anja S Wacker, Chul-Hee Lee, Edward K Fung, Thomas M Jeitner, Onorina L Manzo, Annarita Di Lorenzo, John W Babich, Alejandro Amor-Coarasa, James M Kelly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Impact of CaInternational journal of molecular sciences · 2026
    Review
  2. Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update.Journal of cardiovascular development and disease · 2025
    Review
4 · The record

Corrections and comments

  • Update of
    2-[2024
5 · Who and what money

Authors and funding

10 authors.

Juan A AzconaDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Anja S WackerDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Chul-Hee LeeDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Edward K FungDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Thomas M JeitnerDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Onorina L ManzoDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Annarita Di LorenzoDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
John W BabichDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Alejandro Amor-CoarasaDepartment of Radiology, Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA.
James M KellyDepartment of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA. jak2046@med.cornell.edu.ORCID http://orcid.org/0000-0002-0525-0047

Funding

Major Cyclotron Upgrades and RefurbishmentS10OD030447 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BALLON, DOUGLAS J · 2021 to 2021
$1.6M
PET Imaging Biomarkers to Predict Cardiac Remodeling and Functional Decline in Cardiotoxicity Arising from ChemotherapyR21CA246409 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KELLY, JAMES · 2020 to 2021
$436k
Imaging Incipient Heart Failure by PETF32HL168948 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI AZCONA, JUAN ARTURO · 2023 to 2024
$146k
NCI NIH HHS R21 CA246409NCI NIH HHS R21CA246409-01NHLBI NIH HHS F32 HL168948NHLBI NIH HHS F32HL168948NIH HHS S10 OD030447NIH Office of the Director S10OD030447
6 · The paper itself

Abstract

purposeTreatment of pediatric cancers with doxorubicin is a common and predictable cause of cardiomyopathy. Early diagnosis of treatment-induced cardiotoxicity and intervention are major determinants for the prevention of advanced disease. The onset of cardiomyopathies is often accompanied by profound changes in lipid metabolism, including an enhanced uptake of short-chain fatty acids (SCFA). Therefore, we explored the utility of 2-[ PROCEDURES: Cardiotoxicity and cardiac dysfunction were induced in mice by an 8-dose regimen of doxorubicin (cumulative dose 24 mg/kg) administered over 14 days. The effects of doxorubicin exposure were assessed by measurement of heart weights, left ventricular ejection fractions, and blood cardiac troponin levels. Whole body and cardiac [

resultsSignificantly higher cardiac [

conclusions[

Indexed as

CardiotoxicityDoxorubicinFluorine RadioisotopesPositron-Emission TomographyPropionatesAnimalsHeartMaleMiceMice, Inbred C57BLMonocarboxylic Acid TransportersPyridazinesPyrimidinonesThiophenesAZD3965DoxorubicinFluorine RadioisotopesMonocarboxylic Acid TransportersPropionatespropionic acidPyridazinesPyrimidinonesThiophenes2-[18F]Fluoropropionic acidAZD3965CardiotoxicityDoxorubicinFatty acidsMetabolismMonocarboxylate transporterPositron emission tomographyShort-chain fatty acid

Identifiers

PMID39810069
PMCPMC11805620

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.