Evidence map›Paper›PMID 39810067›Full record

ArticleMolecular imaging and biology2025

Oral Administration of [

Giordana Salvi de Souza, Cristiane R G Furini, Jürgen W A Sijbesma, Maria Kominia, Janine Doorduin, Bruno Lima Giacobbo, Adriaan A Lammertsma, Charalampos Tsoumpas, Gert Luurtsema

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giordana Salvi de SouzaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Cristiane R G FuriniSchool of Medicine, PUCRS, Porto Alegre, Brazil.
Jürgen W A SijbesmaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Maria KominiaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Janine DoorduinDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bruno Lima GiacobboDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Adriaan A LammertsmaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Charalampos TsoumpasDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Gert LuurtsemaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. g.luurtsema@umcg.nl.ORCID http://orcid.org/0000-0001-8599-8129

Funding

Abel Tasman Talent Program (ATTP) of the Graduate School of Medical Sciences of the University of Groningen, the Netherlands. Abel Tasman Talent Program (ATTP) of the Graduate School of Medical Sciences of the University of Groningen, the Netherlands.
6 · The paper itself

Abstract

purposeThis preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointestinal (GI) tract of rats using positron emission tomography (PET) following oral administration of [ PROCEDURES: Twelve male Wistar rats were divided into four groups and subjected to intravenous or oral [

resultsIn the brain, oral administration yielded lower values compared with intravenous administration, resulting in a reduction in the tissue-to-plasma ratio by approximately 51% for the cortex and 45% for the midbrain and cerebellum. Fasting improved radioactivity uptake, aiding brain visualization. Unexpectedly, administration of the P-gp inhibitor tariquidar did not increase brain concentration, suggesting a signal that was dominated by non-specific uptake, possibly due to instability of [

conclusionsOral administration of [

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Fluorine RadioisotopesAdministration, OralAnimalsBrainFeasibility StudiesMalePositron-Emission TomographyRatsRats, WistarTissue DistributionATP Binding Cassette Transporter, Subfamily B, Member 1Fluorine RadioisotopesBiodistributionGastrointestinal tractP-glycoproteinPositron emission tomography

Identifiers

PMID39810067
PMCPMC11805767

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.