Evidence map›Paper›PMID 39809978›Full record

ReviewParasitology research2025

Regulatory B cells in parasitic infections: roles and therapeutic potential.

Haojun Cai, Qianqian Mu, Haiting Xiong, Meichen Liu, Fengjiao Yang, Ling Zhou, Biying Zhou

Abstract readReview
In one paragraph

Review in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haojun CaiSchool of Basic Medicine, Zunyi Medical University, Zunyi, China.
Qianqian MuSchool of Basic Medicine, Zunyi Medical University, Zunyi, China.
Haiting XiongSchool of Basic Medicine, Zunyi Medical University, Zunyi, China.
Meichen LiuSchool of Basic Medicine, Zunyi Medical University, Zunyi, China.
Fengjiao YangSchool of Basic Medicine, Zunyi Medical University, Zunyi, China.
Ling ZhouAffiliated Hospital of Zunyi Medical University, Zunyi, China.
Biying ZhouSchool of Basic Medicine, Zunyi Medical University, Zunyi, China. zbyzl01@126.com.

Funding

National Natural Science Foundation of China No. 81960378
6 · The paper itself

Abstract

Parasitic infection is a complex process involving interactions among various immune cells. Regulatory B cells (Breg cells), a subset of B lymphocytes with immunosuppressive functions, play a role in modulating immune responses during infection to prevent excessive immune activation. This article reviews the origin, phenotype, and immunoregulatory mechanisms of Breg cells. We summarize the immunomodulatory roles of Breg cells in various parasitic infections. We also discuss the potential applications of activating Breg cells through parasitic infections and their derived molecules in the treatment of certain allergic, autoimmune, and inflammatory diseases. The aim is to provide new perspectives for the future treatment of parasitic diseases and other related conditions.

Indexed as

B-Lymphocytes, RegulatoryParasitic DiseasesAnimalsHumansImmunomodulationAllergyImmunoregulationInflammationParasitic infectionsRegulatory B cells

Identifiers

PMID39809978
PMCPMC11732949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.