Evidence map›Paper›PMID 39809971›Full record

ArticleEuropean geriatric medicine2025

Association of falls with risk of dementia and all-cause mortality: a cohort study of Japanese older adults with a 9-year follow-up.

Xiangbin Zhong, Keyang Liu, Yao Yao, Honglin Cai, Baoqing Huang, Xiaojing Yuan, Kokoro Shirai, Katsunori Kondo, Liqi Guan, Qiqing Chen and 2 more

Abstract read
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Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiangbin Zhong *School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Keyang Liu *Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Yao YaoChina Center for Health Development Studies, Peking University, Beijing, China.
Honglin CaiDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Baoqing HuangSchool of Graduate Studies, Lingnan University, Hong Kong SAR, China.
Xiaojing YuanFaculty of Medicine, Macau University of Science and Technology, Macau Special Administrative Region (S.A.R.), China.
Kokoro ShiraiPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Katsunori KondoCenter for Preventive Medical Sciences, Chiba University, Chiba, Japan.
Liqi GuanSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Qiqing ChenSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Xinlei WangSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Yuting LiSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. liyuting@gdpu.edu.cn.ORCID http://orcid.org/0000-0001-6402-6865

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMany risk factors affect dementia and all-cause mortality. However, whether falls are a risk factor for dementia and all-cause mortality is unclear. The study examines the association of falls with the risk of dementia and all-cause mortality, and whether dementia mediates the association of falls with all-cause mortality.

methodsData were taken from the Japanese Gerontological Evaluation Study (JAGES) with a 9-year follow-up. Falls information was collected through a questionnaire and categorized into no falls, single and multiple falls. Dementia and all-cause mortality data were obtained from the long-term care insurance (LTCI) system. The Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs), and causal mediation analysis (CMA) was used to assess the mediating effects of dementia.

resultsA total of 52,076 participants were included in the study. Compared to participants with no falls, participants with single and multiple falls had an increased risk of dementia (single fall, HRs = 1.18, 95% CIs 1.12-1.24; multiple falls, HRs = 1.66, 95% CIs 1.56-1.77) and all-cause mortality (single fall, HRs = 1.09, 95% CIs 1.04-1.15; multiple falls, HRs = 1.34, 95% CIs 1.26-1.43), and the risk increased with the number of falls (P for trend < 0.01). In addition, dementia significantly mediated the association between falls and risk of all-cause mortality (NIE: HRs = 1.02, 95% CIs 1.00-1.04, PM = 15.0%).

conclusionFalls are associated with the risk of dementia and all-cause mortality. Dementia has important mediating effects in the association between falls and the risk of all-cause mortality.

Indexed as

Accidental FallsDementiaMortalityAgedAged, 80 and overCause of DeathCohort StudiesEast Asian PeopleFemaleFollow-Up StudiesHumansJapanMaleProportional Hazards ModelsRisk FactorsAll-cause mortalityDementiaFallsLongitudinal study

Identifiers

PMID39809971

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.