Evidence map›Paper›PMID 39809957›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

Ionised calcium levels during trauma resuscitation in predicting outcomes-a prospective cohort study.

Ramesh Vaidyanathan, Preksha Rani, Shrikanth Manwatkar, J K Singh, Dinesh Gora, Pranabh Kushwaha, Pratyusha Priyadarshini, Dinesh Bagaria, Narendra Choudhary, Junaid Alam and 9 more

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Early calcium replacement after minimal blood transfusion is associated with adverse outcomes.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ramesh VaidyanathanDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Preksha RaniDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Shrikanth ManwatkarDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
J K SinghDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Dinesh GoraDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Pranabh KushwahaDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Pratyusha PriyadarshiniDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Dinesh BagariaDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Narendra ChoudharyDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Junaid AlamDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Arul SelviDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Anand KumarDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Kapil Dev SoniCritical Care and Intensive Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Sushma SagarDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Subodh KumarDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Amit GuptaDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Biplab MishraDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India.
Abhinav KumarDivision of Trauma Surgery and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences [AIIMS], Room 217 Second Floor, New Delhi, India. drabhinav1975@gmail.com.ORCID http://orcid.org/0000-0002-0457-6977
Mahroof KhanDepartment of Biostatics, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHaemorrhage remains the leading cause of preventable mortality following trauma, often aggravated by the acidosis, hypothermia and coagulopathy-the lethal triad of trauma. However, the impact of trauma-induced hypocalcemia on the haemorrhage remains unclear. It is intuitive to consider perturbations of ionised calcium early during trauma resuscitation in acutely injured patients given its pathophysiological significance for an improved outcome. Thus, we conducted a prospective study to analyse the role of ionized calcium ion levels during trauma resuscitation and its association with the need for blood transfusion(s) requirement and mortality.

methodsA prospective study was conducted on acutely injured patients with haemorrhage getting admitted to a Level 1 trauma center in India between September 2020 and June 2022. Ionised calcium was measured on arrival, after 6 h, and on day two of the injury to assess the prevalence. The amount of blood transfusion received by the patient was noted along with other demographic and in-hospital details. The association of hypocalcemia with blood transfusion and mortality was also evaluated.

resultsOf the 1961 patients screened for eligibility, 200 patients were recruited and analysed. 72.5% of patients were hypocalcaemic on emergency department (ED) admission. Ionized hypocalcaemia was significantly associated with the need for blood transfusion(s) (p-value < 0.01). A significant association was also noted between ionized hypocalcaemia and mortality (p-value: 0.0085). On the univariate and multivariable analysis, ionized hypocalcaemia was a significant predictor of mortality.

conclusionsIonized hypocalcaemia is widely prevalent among acutely injured. Trauma-induced hypocalcaemia at admission is associated with increased need for blood transfusions and increased mortality.

Indexed as

CalciumHemorrhageHypocalcemiaResuscitationWounds and InjuriesAdultBlood TransfusionFemaleHumansIndiaMaleMiddle AgedProspective StudiesTrauma CentersCalciumBlood transfusionHaemorrhageIonised calciumMortalityTrauma-induced hypocalcaemiaTrauma resuscitation

Identifiers

PMID39809957

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