ArticleNature structural & molecular biology2025
Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3.
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Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
–field-weighted citation impact
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Who cites it
21 citing papers in PubMed.
- Non-canonical pore architecture underlies constitutive gating of human retinal TRPM1.Nature communications · 2026Article
- Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload.Nature communications · 2026Article
- Temperature and intrinsic CaNature structural & molecular biology · 2026Article
- Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload.bioRxiv : the preprint server for biology · 2026Article
- Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3.Nature communications · 2026Article
- Functional and structural basis of a hypermorphic TRPC3 variant.Science advances · 2026Article
- Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.Nature communications · 2026Article
- TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy.Cell reports. Medicine · 2026Article
- A single allosteric site merges activation, modulation and inhibition in TRPM5.Nature chemical biology · 2026Article
- Polypharmacology of anthelmintics at host and parasite ion channels.PLoS pathogens · 2026Article
- A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3.Communications chemistry · 2026Article
- Structural basis for agonist and heat activation of nociceptor TRPM3.Nature structural & molecular biology · 2026Article
- Temperature-induced structural changes in thermosensitive transient receptor potential channels (thermoTRPs).Frontiers in molecular neuroscience · 2026Review
- Visualizing insecticide control of insect TRP channel function and assembly.Nature communications · 2025Article
- Molecular architecture of the human TRPC1/C5 heteromeric channel.Nature communications · 2025Article
- Direct crosstalk between GPCRs and ion channels via G proteins.Experimental & molecular medicine · 2025Review
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- The ExPAND Study: A Prospective Association Study into Endometriosis-Associated Pain, Neurosteroid Synthesis, and TRPM3.Biomolecules · 2025Article
- Stimulation of Transient Receptor Potential Channels TRPM3 and TRPM8 Increases Human Prostaglandin Endoperoxide Synthase-2 Promoter Activity.Molecules (Basel, Switzerland) · 2025Article
- Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3.Nature structural & molecular biology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Ying YinDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-4128-8616
Cheon-Gyu ParkDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-4739-1913
Shasha FengDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.ORCID http://orcid.org/0000-0003-3394-6911
Ziqiang GuanDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8082-3423
Hyuk-Joon LeeDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-7568-2307
Feng ZhangDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Kedar SharmaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-6679-2341
Mario J BorgniaDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9159-1413
Wonpil ImDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.ORCID http://orcid.org/0000-0001-5642-6041
Seok-Yong LeeDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA. seok-yong.lee@duke.edu.ORCID http://orcid.org/0000-0002-0662-9921
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MNIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0MStructure, function, and pharmacology of neuronal membrane transport proteinsR35NS097241 · NINDS · DUKE UNIVERSITY · PI LEE, SEOK-YONG · 2016 to 2023
$6.1MRoles of novel cationic lipids in bacterial pathogenesisR01AI178692 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI Kelly S Doran, Ziqiang Guan · 2023 to 2026
$2.6MAdaptive alterations of lipids in mitis group streptococciR01AI148366 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI GUAN, ZIQIANG, PALMER, KELLI LEA · 2020 to 2024
$2.5MCHARMM-GUI Development for Biomolecular Modeling and Simulation CommunityR01GM138472 · NIGMS · LEHIGH UNIVERSITY · PI IM, WONPIL · 2020 to 2023
$1.5MIntramural NIH HHS ZIC ES103326NCI NIH HHS 75N91019D00024NIAID NIH HHS R01 AI148366NIAID NIH HHS R01 AI178692NIGMS NIH HHS R01 GM138472NINDS NIH HHS R35 NS097241
Abstract
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca
Indexed as
AnticonvulsantsNeurosteroidsPregnenoloneTRPM Cation ChannelsAnimalsBinding SitesCryoelectron MicroscopyHumansMiceModels, MolecularMutationAnticonvulsantsNeurosteroidsPregnenolonepregnenolone sulfateTRPM3 protein, mouseTRPM Cation Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.