ArticleNature biotechnology2025
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.
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Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nanomaterials targeting ferroptosis for osteoarthritis treatment: a systematic review of preclinical evidence.Journal of nanobiotechnology · 2026Pooled it
- Visual theranostic oral nanozymes for IBD from principles to preclinical design.Bioactive materials · 2026Review
- Quantitative single cell analysis of gold nanoparticle association across a mouse triple-negative breast cancer cell line and blood immune cell populations.Analytical and bioanalytical chemistry · 2026Article
- Review
- Lipid nanoparticles as active biointerfaces: From membrane interaction to systemic dysregulation.Acta pharmaceutica Sinica. B · 2026Review
- Advances in improving cancer immunotherapy with nanotechnology: from smart nanoparticles to synergistic combination strategies.Molecular cancer · 2026Review
- AI meets high-throughput screening of LNPs.Nature biomedical engineering · 2026Article
- Article
- CAR-neutrophils produced in vivo to treat glioma.Nature biomedical engineering · 2026Article
- Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting.ACS applied materials & interfaces · 2026Article
- Nanoparticle-Based Tolerogenic Vaccines: Next-Generation Strategies for Autoimmune and Allergic Disease Therapies.Angewandte Chemie (International ed. in English) · 2026Review
- Ultra-Fast Isothermal Formation of DNA Nanostructures in Culture Media: Application to In Situ Assembly of DNA Origami With Living Cells.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Barrier-to-Design Codes for Organ-Targeted Nanomedicine: A Framework Linking Barrier Phenotypes to Nano-Bio Interface Design and Translational Validation.International journal of nanomedicine · 2026Review
- Current progress of labeling strategies in tissue clearing for large-scale biological visualization.Frontiers in cell and developmental biology · 2026Review
- Advances in Optical Tissue Clearing for Three-Dimensional Ocular Imaging and Analysis.Journal of ophthalmology · 2026Review
- Immunology of RNA-based vaccines: The critical interplay between inflammation and expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.Nature biotechnology · 2025Article
- Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier.Journal of nanobiotechnology · 2025Review
- Single-Frame Vignetting Correction for Post-Stitched-Tile Imaging Using VISTAmap.Nanomaterials (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors.
Jie Luo *Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Muge Molbay *Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Ying Chen *Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Izabela Horvath *Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-1702-2869
Karoline Kadletz *Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Benjamin Kick *Department of Biosciences, School of Natural Sciences, Technical University of Munich, Garching, Germany.
Shan Zhao *Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Rami Al-MaskariInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Inderjeet SinghResearch Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
Mayar AliInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Harsharan Singh BhatiaInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
David-Paul MindeInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Moritz NegwerInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Luciano HoeherInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Gian Marco CalandraInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.
Bernhard GroschupInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.
Jinpeng SuInstitute of Virology, Technical University of Munich / Helmholtz Munich, Munich, Germany.
Ceren KimnaInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-2283-4295
Zhouyi RongInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-4849-1278
Nikolas GalensowskeInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Mihail Ivilinov TodorovInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8627-1260
Denise JeridiInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Tzu-Lun OhnInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Stefan RothInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.
Alba SimatsInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.
Vikramjeet SinghInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7361-8317
Igor KhalinInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.
Chenchen PanInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Bernardo A ArúsDepartment of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.ORCID http://orcid.org/0000-0001-6132-7793
Oliver T BrunsDepartment of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
Reinhard ZeidlerHelmholtz Zentrum München, German Research Center for Environmental Health, Institute of Structural Biology, Munich, Germany.ORCID http://orcid.org/0000-0002-3357-4954
Arthur LieszInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-9069-2594
Ulrike ProtzerInstitute of Virology, Technical University of Munich / Helmholtz Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-9421-1911
Nikolaus PlesnilaInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-8832-228X
Siegfried UssarResearch Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-7575-0920
Farida HellalInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Johannes PaetzoldInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Markus ElsnerInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-7227-5212
Hendrik DietzDepartment of Biosciences, School of Natural Sciences, Technical University of Munich, Garching, Germany. dietz@tum.de.ORCID http://orcid.org/0000-0003-1270-3662
Ali ErturkInstitute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany. ali.erturk@helmholtz-munich.de.ORCID http://orcid.org/0000-0001-5163-5100
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision Nanocarrier Identification (SCP-Nano), an integrated experimental and deep learning pipeline to comprehensively quantify the targeting of nanocarriers throughout the whole mouse body at single-cell resolution. SCP-Nano reveals the tissue distribution patterns of lipid nanoparticles (LNPs) after different injection routes at doses as low as 0.0005 mg kg
Indexed as
Deep LearningDrug CarriersNanoparticlesSingle-Cell AnalysisAnimalsCOVID-19DependovirusDrug Delivery SystemsHumansLipidsLiposomesMiceSARS-CoV-2Spike Glycoprotein, CoronavirusTissue DistributionDrug CarriersLipid NanoparticlesLipidsLiposomesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.