ArticleNature genetics2025
The NAT1-bHLH110-CER1/CER1L module regulates heat stress tolerance in rice.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026Review
- Targeting the Light-Harvesting Complex I Gene Lhca4 Confers Saline-Alkali Tolerance in Rice Without Yield Penalty.Plant, cell & environment · 2026Article
- Shaping Plant Adaptation in a Warmer World: Developmental Plasticity Under Moderately Elevated Temperatures.Plants (Basel, Switzerland) · 2026Review
- Integrating molecular networks and physiological adaptation for heat-resilient crops.Journal of integrative plant biology · 2026Review
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Signal peptide peptidase-like proteases OsSPPL1 and OsSPPL2 facilitate ER-associated protein degradation in rice.Nature communications · 2026Article
- Transcription Profiling of Potato Leaves in Response to Heat Stress at Single-Cell Resolution.Plant biotechnology journal · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- The miR396f-GRF7 Module Confers Thermotolerance in Rice.Rice (New York, N.Y.) · 2026Article
- Transcriptomic and DNA methylation insights into polyploidy-enhanced heat tolerance in rice (Oryza sativa L.).Plant physiology · 2026Article
- OsMYB99 Modulates Grain Wax Biosynthesis and Redox Homeostasis to Control Head Rice Yield and Chalkiness.Plant biotechnology journal · 2026Article
- TaHST2 silencing shapes basal heat tolerance in allohexaploid wheat.Nature plants · 2026Article
- The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors.Biology · 2026Review
- Genome-Wide Characterization of Nuclear Factor Y (NF-Y) Transcription Factors Gene Family in Cabbage (International journal of molecular sciences · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Provide Insights into the Response of Red Clover (International journal of molecular sciences · 2026Article
- The Role and Regulatory Mechanisms of Cuticular Wax in Crop Stress Tolerance and Yield.Plants (Basel, Switzerland) · 2026Review
- Comparative Genomic Analysis and Functional Identification of CER1 and CER3 Homologs in Rice Wax Synthesis.Biology · 2026Article
- Integrated multi-omics analysis reveals candidate genes for cuticular wax biosynthesis and molecular characteristics of a glossy mutant in rapeseed under natural drought stress.Frontiers in plant science · 2026Article
- Integrative hologenomic analysis reveals apolipoprotein D-associated host-microbe metabolic crosstalk linked to fat deposition in Jinhua pigs.Frontiers in microbiology · 2026Article
- Heat stress-induced metabolomic shifts in chickpea (Cicer arietinum L.) flowers insights from contrasting genotypes.Scientific reports · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Rice production is facing substantial threats from global warming associated with extreme temperatures. Here we report that modifying a heat stress-induced negative regulator, a negative regulator of thermotolerance 1 (NAT1), increases wax deposition and enhances thermotolerance in rice. We demonstrated that the C2H2 family transcription factor NAT1 directly inhibits bHLH110 expression, and bHLH110 directly promotes the expression of wax biosynthetic genes CER1/CER1L under heat stress conditions. In situ hybridization revealed that both NAT1 and bHLH110 are predominantly expressed in epidermal layers. By using gene-editing technology, we successfully mutated NAT1 to eliminate its inhibitory effects on wax biosynthesis and improved thermotolerance without yield penalty under normal temperature conditions. Field trials further confirmed the potential of NAT1-edited rice to increase seed-setting rate and grain yield. Therefore, our findings shed light on the regulatory mechanisms governing wax biosynthesis under heat stress conditions in rice and provide a strategy to enhance heat resilience through the modification of NAT1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.