Evidence map›Paper›PMID 39809874›Full record

ArticleNPJ digital medicine2025

Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment.

Jun J Mao, Karolina Bryl, Erin F Gillespie, Angela Green, Tony K W Hung, Raymond Baser, Katherine Panageas, Michael A Postow, Bobby Daly

Registry-linked trialAbstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05053230 (Integrative Medicine for Patient-reported Outcomes, Values, and Experience), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05053230 naactive not recruitingnot on this map

Integrative Medicine for Patient-reported Outcomes, Values, and Experience (IMPROVE)

TypeinterventionalSponsorMemorial Sloan Kettering Cancer CenterRan2021 to 2026Enrolled324ConditionsHead and Neck Cancer, Head and Neck Tumor, Thoracic Tumor, Thoracic CancerArmsIM@Home, Enhanced usual care
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
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  3. Implementation and evaluation of an integrated ayurveda-yoga education program for lifestyle modifications among people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun J MaoIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. maoj@mskcc.org.
Karolina BrylIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-1804-367X
Erin F GillespieDepartment of Radiation Oncology, University of Washington School of Medicine / Fred Hutchinson Cancer Center, Seattle, WA, 98195, USA.
Angela GreenGynecologic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Tony K W HungHead and Neck Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Raymond BaserDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-1644-4090
Katherine PanageasDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Michael A PostowMelanoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Bobby DalyThoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Research & Methods CoreP50CA271357 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MICHAEL J MORRIS, KATHERINE S PANAGEAS · 2022 to 2026
$7.7M
Leveraging implementation science to accelerate adoption of shorter-course radiation for breast and prostate cancerK08CA252640 · NCI · UNIVERSITY OF WASHINGTON · PI GILLESPIE, ERIN FAYE · 2020 to 2025
$1.3M
NCI NIH HHS K08 CA252640NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA271357U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1P50CA271357-01
6 · The paper itself

Abstract

Exercise and mindfulness-based interventions have growing evidence for managing fatigue and comorbid symptoms; however, packaging them in a cohesive digital way for patients undergoing cancer treatment has not been evaluated. We conducted a randomized controlled trial to assess the impact of a 12 week digital integrative medicine program, Integrative Medicine at Home (IM@Home), versus enhanced usual care on fatigue severity (primary outcome), comorbid symptoms and acute healthcare utilization (secondary outcomes), in 200 patients with solid tumors experiencing fatigue during treatment. Fatigue severity decreased more in IM@Home than in the control (1.99 vs. 1.51 points; p = 0.04). IM@Home participants also had reduced symptom distress (p = 0.003), anxiety (p = 0.03), and depression (p = 0.02). Acute healthcare utilization was lower with IM@Home, with fewer emergency department visits (rate ratio 0.49; p = 0.04), hospitalizations (4% vs. 12.9%; p = 0.03), and shorter hospital stays (4.25 vs. 10 days; p < 0.001). These promising findings should be confirmed in phase III clinical trials. "Study registered at clinicaltrials.gov (NCT05053230) on 09-20-2021".

Identifiers

PMID39809874
PMCPMC11733120

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.