ArticleScientific reports2025
Systemic inflammatory response index improves prognostic predictive value in intensive care unit patients with sepsis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive value of systemic immune-inflammation index in patients with diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Comparative Analysis of Novel Inflammatory and Nutritional Indices (m-HALP, HALP, SII, SIRI) for Risk Stratification in Septic Patients: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Evaluation of Selected Laboratory Parameters as Predictive Biomarkers of Clinical Response to Dupilumab Therapy in Patients with Atopic Dermatitis.Biomedicines · 2026Article
- Evaluation of Systemic Inflammatory Indices in Pregnant Women With Deep Vein Thrombosis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Preoperative Systemic Inflammatory Response Index (SIRI) as a predictor of early surgical site infection following instrumented lumbar spine surgery.International orthopaedics · 2026Article
- Clinical Importance of the Inflammatory Prognostic Index in Patients with Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- Risk factors for severe retinopathy of prematurity: A retrospective case-control study.Experimental and therapeutic medicine · 2026Article
- Article
- Association Between Inflammatory Cytokines and Systemic Inflammation Indices in Patients With Psoriasis: A Cross-Sectional Study.Health science reports · 2026Article
- Systemic Inflammatory Response Index (SIRI) Among Patients With Sepsis: A Retrospective Observational Study.Cureus · 2026Article
- Systemic inflammation response index predicts short-term mortality in intensive care unit patients with bacterial bloodstream infections.BMC infectious diseases · 2026Article
- Diagnostic and prognostic utility of SIRI and CAR in necrotizing fasciitis: a retrospective cohort study on disease severity and clinical outcomes.European journal of medical research · 2026Article
- Article
- Association Between the Systemic Inflammatory Response Index and Severe Infection in Patients with Diabetic Foot.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Inflammatory markers and increased risk of chronic kidney disease in patients with coronary artery disease: findings from a multicenter cohort study.Frontiers in endocrinology · 2026Observational
- Prognostic Value of Systemic Inflammatory Indices in Hospitalized Patients with HFrEF: A Multicenter Retrospective Cohort Study.International journal of general medicine · 2026Article
- The Systemic Inflammation Response Index (SIRI) for Stratifying Mortality Risk in Multidrug-Resistant Lower Respiratory Tract Infections Acquired in Hospital Settings.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Shapiro Decision Rule, Systemic Inflammatory Response Index, and Systemic Immune-Inflammation Index as Rapid Predictors of Bacteremia in Emergency Department Patients.Infection and drug resistance · 2026Article
- A Prognostic Model Based on Immune-Inflammatory-Nutritional Indicators for 28-Day Mortality in Sepsis Patients with Acute-on-Chronic Liver Failure.Journal of inflammation research · 2026Article
- Comparative value of novel inflammatory indices in predicting incident carotid atherosclerosis: SIRI outperforms other markers in a general population.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Sepsis is a severe infectious disease with high mortality. However, the indicators used to evaluate its severity and prognosis are relatively complicated. The systemic inflammatory response index (SIRI), a new inflammatory indicator, has shown good predictive value in chronic infection, stroke, and cancer. The purpose of this study was to investigate the connection between sepsis and SIRI and evaluate its predictive usefulness. A total of 401 patients with sepsis were included in this study. Multiple linear regression and logistic regression analyses were performed to evaluate the relationship between SIRI and sepsis. The restricted cubic spline (RCS) method was employed to illustrate the dose-response relationship. The area under the curve (AUC) and decision curve analysis (DCA) were used to evaluate the prognostic value of SIRI. Multiple linear regression analysis revealed a significant positive correlation between SIRI and both blood cell count and Sequential Organ Failure Assessment (SOFA) score. Additionally, higher SIRI levels were significantly linked to a higher risk of sepsis worsening, according to logistic regression analysis. The RCS curve demonstrated that the risk of poor prognosis rose with increasing SIRI, particularly when SIRI exceeded 6.1. Furthermore, AUC and DCA results showed that SIRI had superior predictive value compared to traditional indicators. A higher SIRI is linked to a worse prognosis and more severe sepsis. SIRI may serve as a novel prognostic indicator in sepsis, though further clinical studies are necessary to confirm these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.