Evidence map›Paper›PMID 39809846›Full record

ArticleMolecular psychiatry2025

Altered tRNA expression profile associated with codon-specific proteomic changes in the suicide brain.

J Blaze, S Chen, S Heissel, H Alwaseem, M P Landinez Macias, C Peter, H Molina, E Storkebaum, G Turecki, H Goodarzi and 1 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A Cross-Matrix Peripheral Transcriptional Signature in Suicide Attempt:International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

J Blaze *Department of Psychiatry, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jenniferblaze@gmail.com.ORCID 0000-0002-4156-0624
S Chen *Department of Biochemistry and Biophysics, Department of Urology, Helen Diller Cancer Center, University of California San Francisco, San Francisco, CA, USA.
S HeisselProteomics Resource Center, The Rockefeller University, New York, NY, USA.
H AlwaseemProteomics Resource Center, The Rockefeller University, New York, NY, USA.
M P Landinez MaciasMolecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0003-0304-5629
C PeterDepartment of Psychiatry, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9190-8724
H MolinaProteomics Resource Center, The Rockefeller University, New York, NY, USA.
E StorkebaumMolecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, The Netherlands.
G TureckiMcGill Group for Suicide Studies, Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.ORCID 0000-0003-4075-2736
H GoodarziDepartment of Biochemistry and Biophysics, Department of Urology, Helen Diller Cancer Center, University of California San Francisco, San Francisco, CA, USA.
S AkbarianDepartment of Psychiatry, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7700-0891

Funding

Functional genomic resource and integrative model of dopaminergic circuitry associated with psychiatric diseaseU01DA048279 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BRENNAND, KRISTEN JENNIFER · 2019 to 2023
$3.5M
TRANSCRIPTOME AND EPIGENOME MAPPING IN DOPAMINE NEURONS FROM THE OPIOID EXPOSED HUMAN BRAINR01DA047880 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BANNON, MICHAEL J · 2019 to 2023
$3.4M
RNA cytosine methylation in the rodent prefrontal cortexF32MH115565 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLAZE, JENNIFER · 2018 to 2020
$188k
American Foundation for Suicide Prevention (AFSP) YIG-1-013-21NIDA NIH HHS R01 DA047880NIDA NIH HHS U01 DA048279NIMH NIH HHS F32 MH115565
6 · The paper itself

Abstract

Suicide is a major public health concern, and the number of deaths by suicide has been increasing in recent years in the US. There are various biological risk factors for suicide, but causal molecular mechanisms remain unknown, suggesting that investigation of novel mechanisms and integrative approaches are necessary. Transfer (t)RNAs and their modifications, including cytosine methylation (m

Indexed as

RNA, TransferSuicideAdultAnimalsBrainCodonFemaleHumansMajor Depressive DisorderMaleMetabolomicsMiceMiddle AgedPrefrontal CortexProteomeProteomicsCodonProteomeRNA, Transfer

Identifiers

PMID39809846
PMCPMC12185327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.