Evidence map›Paper›PMID 39809837›Full record

ArticleScientific reports2025

Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping.

Hannah L Cornman, Martin P Alphonse, Arbor Dykema, Alexander L Kollhoff, Kevin K Lee, Jaya Manjunath, Emily Z Ma, Varsha Parthasarathy, Junwen Deng, Thomas Pritchard and 8 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hannah L CornmanDepartment of Dermatology, University of Maryland School of Medicine, 419 West Redwood Street, Suite 235, Baltimore, MD, 21201, USA.
Martin P AlphonseDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arbor DykemaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexander L KollhoffDepartment of Dermatology, University of Maryland School of Medicine, 419 West Redwood Street, Suite 235, Baltimore, MD, 21201, USA.
Kevin K LeeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jaya ManjunathDepartment of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Emily Z MaDepartment of Dermatology, University of Maryland School of Medicine, 419 West Redwood Street, Suite 235, Baltimore, MD, 21201, USA.
Varsha ParthasarathyDepartment of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Junwen DengDepartment of Dermatology, University of Maryland School of Medicine, 419 West Redwood Street, Suite 235, Baltimore, MD, 21201, USA.
Thomas PritchardDepartment of Dermatology, University of Maryland School of Medicine, 419 West Redwood Street, Suite 235, Baltimore, MD, 21201, USA.
Anusha KambalaDepartment of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Melika MaraniDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kayla A ParrDuke Cancer Institute Flow Cytometry Core, Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
Javid P MohammedDuke Cancer Institute Flow Cytometry Core, Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
Madan M KwatraDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
Jay H BreamDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Won Jin HoDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shawn G KwatraDepartment of Dermatology, University of Maryland School of Medicine, 419 West Redwood Street, Suite 235, Baltimore, MD, 21201, USA. skwatra@som.umaryland.edu.

Funding

Racial Differences in Biomarkers and Therapeutic Targets for Chronic ItchK23AR077073 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI KWATRA, SHAWN GAURAV · 2021 to 2025
$873k
NIAMS NIH HHS K23 AR077073NIH HHS K23AR077073
6 · The paper itself

Abstract

Erythroderma is a severe and heterogeneous inflammatory skin condition with little guidance on the approach to management in cases of unknown etiology. To guide therapeutic selection, we sought to create an immunophenotyping platform able to identify aberrant cell populations and cytokines in subtypes of erythroderma. We performed high-parameter flow cytometry on peripheral blood mononuclear cells (PBMCs) and whole blood of a patient with refractory idiopathic erythroderma, erythrodermic patients with Sézary syndrome and pityriasis rubra pilaris, and healthy controls. We found that the index patient had a novel form of erythroderma characterized by increased interleukin (IL)-13- and IL-17-producing γVδ2 T cells, basophils, and activated platelets. Whole-genome sequencing of PBMCs and immunofluorescence staining of skin biopsies revealed increased expression of Th2- (IL-13, IL-4Rα) and Th17-associated markers (IL-17, IL-17Rα) and non-functional mutations associated with Th2 and Th17 signaling, demonstrating that PBMCs can reflect cutaneous disease pathology. Targeted intervention via dual dupilumab and secukinumab therapy resulted in complete disease control and reduction of immunopathogenic cell populations and cytokines. This study highlights a novel form of erythroderma with concomitant Th2 and Th17 dysregulation and introduces a minimally invasive peripheral blood-based immunophenotyping platform that offers a personalized medicine approach to the management of systemic inflammatory diseases.

Indexed as

Dermatitis, ExfoliativeImmunophenotypingAdultAntibodies, Monoclonal, HumanizedCytokinesFemaleHumansInterleukin-17Leukocytes, MononuclearMaleMiddle AgedAntibodies, Monoclonal, HumanizedCytokinesInterleukin-17

Identifiers

PMID39809837
PMCPMC11733286

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.