Evidence map›Paper›PMID 39809824›Full record

Observational studyScientific reports2025

Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China.

Renliang Huang, Zhe Lu, Xinze Li, Duo Zhou, Jing Xu, Dan Lin, Yunxue Fu, Yan Liang, Xuexia Li, Frank Petersen and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Renliang HuangHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Zhe LuHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Xinze LiNHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, Hainan, China.
Duo ZhouHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Jing XuHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Dan LinHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Yunxue FuHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Yan LiangHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
Xuexia LiNHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, Hainan, China.
Frank PetersenPriority Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, 23845, Germany.
Qiaomiao ZhouHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China. zhouqiaomiao@163.com.
Xinhua YuHainan Women and Children's Medical Center, Haikou, 571199, Hainan, China. xinhuayu@fz-borstel.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This observational investigation aimed to explore potential risk factors for anemia in pregnancy. Firstly, a cross-sectional study was conducted, encompassing a review of clinical data of 43,201 pregnant women admitted to the Hainan Women and Children's Medical Center between January 2017 and December 2020. Comparison between women with and without anemia in pregnancy revealed significant differences between the two groups concerning age, gestational diabetes, hypothyroidism, hyperthyroidism, chronic hepatitis B virus infection, syphilis infection, and human immunodeficiency virus infection. Multivariable logistic regression analysis showed that chronic hepatitis B virus infection was significantly associated with anemia during pregnancy (AOR   2.97, 95% CI 2.57-3.44, p < 0.0001). Subsequently, a retrospective cohort comprising 86 cases with chronic hepatitis B virus infection and 129 control subjects recruited from the Hainan Women and Children's Medical Center from November 2021 and January 2023 was examined. Results of the examination revealed a corroborative association between chronic hepatitis B virus infection and anemia in pregnancy (OR  2.13, 95% CI 1.20-3.79, p = 0.0092), particularly manifesting in the third trimester of gestation. Further analysis unveiled distinctive hematological alterations among cases with chronic hepatitis B virus infection, characterized by diminished erythrocyte size and reduced levels of corpuscular hemoglobin. Collectively, these findings underscore a positive association of chronic hepatitis B virus infection with anemia during pregnancy.

Indexed as

AnemiaHepatitis B, ChronicPregnancy Complications, HematologicPregnancy Complications, InfectiousAdultChinaCross-Sectional StudiesFemaleHepatitis B virusHumansPregnancyRetrospective StudiesRisk FactorsYoung AdultAnemia in pregnancyAssociationHepatitis B virusInfectionObservational study

Identifiers

PMID39809824
PMCPMC11732989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.