Evidence map›Paper›PMID 39809778›Full record

ArticleNature communications2025

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT.

Chloe Seddon, Sophia David, Joshua L C Wong, Naito Ishimoto, Shan He, Jonathan Bradshaw, Wen Wen Low, Gad Frankel, Konstantinos Beis

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Liganded LolCDE structures reveal a common substrate-LolE interaction guiding bacterial lipoprotein transport.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Transfer potential of F-like plasmids inISME communications · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The extended mobility of plasmids.Nucleic acids research · 2025
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chloe Seddon *Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Sophia David *Centre for Genomic Pathogen Surveillance, Pandemic Sciences Institute, University of Oxford, Oxford, OX3 7DQ, UK.ORCID http://orcid.org/0000-0002-0115-0954
Joshua L C WongDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.ORCID http://orcid.org/0000-0001-8437-6731
Naito IshimotoDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.ORCID http://orcid.org/0000-0001-8976-8582
Shan HeDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.ORCID http://orcid.org/0009-0001-0452-9417
Jonathan BradshawDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Wen Wen LowDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Gad FrankelDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK. g.frankel@imperial.ac.uk.ORCID http://orcid.org/0000-0002-0046-1363
Konstantinos BeisDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK. kbeis@imperial.ac.uk.ORCID http://orcid.org/0000-0001-5727-4721

Funding

Gates Foundation INV-025280RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M011178/1Wellcome TrustWellcome Trust (Wellcome) 107057/z/15/z and 224282/Z/21/Z
6 · The paper itself

Abstract

Conjugation plays a major role in dissemination of antimicrobial resistance genes. Following transfer of IncF-like plasmids, recipients become refractory to a second wave of conjugation with the same plasmid via entry (TraS) and surface (TraT) exclusion mechanisms. Here, we show that TraT from the pKpQIL and F plasmids (TraT

Indexed as

Bacterial ProteinsConjugation, GeneticEvolution, MolecularCryoelectron MicroscopyPhylogenyPlasmidsBacterial Proteins

Identifiers

PMID39809778
PMCPMC11733297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.