Evidence map›Paper›PMID 39809701›Full record

ArticlePharmacogenomics2024

Priyanga Ranasinghe, Pulasthi B Gunarathna, Hajanthy Jeyapragasam, Nirmala Sirisena, D P Bhagya Hendalage, Vajira H W Dissanayake

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priyanga RanasingheDepartment of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID 0000-0002-1522-9276
Pulasthi B GunarathnaDepartment of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID 0009-0005-3175-2445
Hajanthy JeyapragasamDepartment of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID 0009-0002-0802-4712
Nirmala SirisenaDepartment of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID 0000-0003-0994-6954
D P Bhagya HendalageDepartment of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID 0009-0006-6228-6333
Vajira H W DissanayakeDepartment of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID 0000-0002-3264-6856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsClopidogrel exhibits substantial variability in therapeutic response, largely contributed by genetic factors. The pharmacogenomic variants data on clopidogrel metabolism in South Asians have been sparsely studied. This study explores the impact of MATERIALS &

methodsGenotype data were filtered out from an anonymized database of 690 Sri Lankans, and minor allele frequencies (MAFs) were calculated. Five variants of

resultsAmong the five

conclusionGiven that South Asians share genetic similarities, these findings suggest that a substantial proportion of the region's population may also be poor responders to clopidogrel, increasing the risk of adverse outcomes. This highlights the importance of genotype-guided antiplatelet therapy, which could improve clinical outcomes across South Asia amidst rising cardiovascular disease rates.

Indexed as

Carboxylic Ester HydrolasesClopidogrelCytochrome P-450 CYP2C19Platelet Aggregation InhibitorsSouth Asian PeopleFemaleGene FrequencyGenetic VariationGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideSri LankaCarboxylic Ester HydrolasesCES1 protein, humanClopidogrelCYP2C19 protein, humanCytochrome P-450 CYP2C19Platelet Aggregation InhibitorsCES1 gene-variantsClopidogrelCYP2C19individualized medicinepharmacogenomics

Identifiers

PMID39809701
PMCPMC11901400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.