ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2025
Mass Spectrometry-Based Applications of Spheroids in Cancer Biology.
Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Localized Accumulation of Tri-n-Propylamine Prolongs Electrochemiluminescence for Tumor Model Spheroid Analysis.Angewandte Chemie (International ed. in English) · 2026Article
- Minimizing the Coffee Ring Effect: Improving MALDI Dried-Drop Analysis by Sequential Spotting.Journal of the American Society for Mass Spectrometry · 2026Article
- Integrative proteomics and metabolomics advance early cancer detection and targeted therapy with emerging technologies and clinical applications.Discover oncology · 2026Review
- From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The use of cell culture techniques to model human disease is an indispensable tool that has helped improve the health and well-being of the world. Monolayer cultures have most often been used for biomedical research, although not accurately recapitulating an in vivo human tumor. Tumor spheroids are a form of three-dimensional cell culture that better mimics an avascularized human tumor through their cell-cell contacts in all directions, development of various chemical gradients, and distinct populations of cells found within the spheroid. In this review, we highlight how mass spectrometry has propelled the utility of the spheroid model to understand cancer biology. We discuss how mass spectrometry imaging can be utilized to determine the penetration efficiency of various chemotherapeutics, how proteomics can be used to understand the biology in the various layers of a spheroid, and how metabolomics and lipidomics are used to elucidate how various spheroids behave toward chemotherapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.