ArticleMedicine and science in sports and exercise2025
Reduced Lower Body Muscular Strength and Endurance among Adult Survivors of Childhood Cancer.
Article in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bone Loss, Osteoporosis, and Skeletal Fragility: Hidden Consequences of Cancer Cachexia.Cells · 2026Review
- Cohort Profile Update: The Swiss Childhood Cancer Survivor Cohort.International journal of epidemiology · 2026Article
- Metabolomics-based exploration of the pathogenesis of breast cancer-related fatigue and progress of traditional Chinese medicine intervention.Frontiers in oncology · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionImpaired physical fitness is a possible late effect among adult survivors of childhood cancer (ASCC). Our study describes lower body muscular strength and endurance among ASCC using the 1-min sit-to-stand (1-min STS) test, compares them with the general population, identifies risk factors, and describes changes over time.
methodsIn a prospective multicenter cohort study, we invited ASCC ≥18 yr of age at study who were diagnosed between ages 0 and 20 yr, treated in five pediatric oncology centers across Switzerland from 1976 to 2017, and survived ≥5 yr for a 1-min STS test. We collected information about lifestyle, medical history, and previous cancer treatment. Using population-based Swiss reference values, we calculated age- and sex-adjusted z -scores for 1-min STS performance and assessed the association between risk factors and 1-min STS test using multivariable linear regression. We fitted a multilevel linear model to describe the longitudinal course of 1-min STS performance.
resultsWe included 338 CCS of 1048 invited ASCC (participation rate 32%) with a median age at study of 34 yr (interquartile range, 26-41 yr). Compared with the general population, mean 1-min STS z -score was half a standard deviation lower (-0.52; 95% confidence interval (CI), -0.64 to -0.40). Obesity ( B = -0.56; 95% CI, -0.97 to -0.16), cumulative cisplatin dose ( B = -0.12; 95% CI, -0.21 to -0.02), and cumulative cranial radiotherapy dose ( B = -0.10; 95% CI, -0.19 to -0.01) were associated with reduced 1-min STS performance. There was no change in 1-min STS z -scores over time ( B = 0.02; 95% CI, -0.05 to 0.09).
conclusionsWe found evidence for reduced lower body strength and endurance among ASCC, suggesting the need for counseling and effective training and rehabilitation programs for maintaining daily functioning, improving cardiovascular health, and reducing morbidity for ASCC.
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