Evidence map›Paper›PMID 39809079›Full record

ArticleBiomaterials2025

Spaceflight alters protein levels and gene expression associated with stress response and metabolic characteristics in human cardiac spheroids.

Parvin Forghani, Wenhao Liu, Zeyu Wang, Zhi Ling, Felipe Takaesu, Evan Yang, Gregory K Tharp, Sheila Nielsen, Shankini Doraisingam, Stefanie Countryman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Parvin ForghaniDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Wenhao LiuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Zeyu WangSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Zhi LingWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Felipe TakaesuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Evan YangWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Gregory K TharpEmory National Primate Research Center, Emory University, Atlanta, GA, USA.
Sheila NielsenBioServe Space Technologies, Boulder, CO, USA.
Shankini DoraisingamBioServe Space Technologies, Boulder, CO, USA.
Stefanie CountrymanBioServe Space Technologies, Boulder, CO, USA.
Michael E DavisDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Ronghu WuSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Shu JiaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Chunhui XuDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. Electronic address: chunhui.xu@emory.edu.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Toward Systems Biophotonics: Imaging Biology across High Dimensions and ScalesR35GM124846 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Shu Jia · 2017 to 2026
$4.0M
Alcohol-induced cardiac injury and repair in human induced pluripotent stem cell modelR01AA028527 · NIAAA · EMORY UNIVERSITY · PI XU, CHUNHUI · 2021 to 2025
$1.8M
NIAAA NIH HHS R01 AA028527NIGMS NIH HHS R35 GM124846NIH HHS P51 OD011132
6 · The paper itself

Abstract

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess tremendous advantage for cardiac regeneration. However, cell survival is challenging upon cell transplantation. Since microgravity can profoundly affect cellular properties, we investigated the effect of spaceflight on hiPSC-CMs. Cardiac spheroids derived from hiPSCs were transported to the International Space Station (ISS) via the SpaceX Crew-8 mission and cultured under space microgravity for 8 days. Beating cardiac spheroids were observed on the ISS and upon successful experimentation by the astronauts in space, the live cultures were returned to Earth. These cells had normal displacement (an indicator of contraction) and Ca

Indexed as

Gene Expression RegulationMyocardiumProteinsSpace FlightSpheroids, CellularStress, PhysiologicalCalcium SignalingCell ProliferationCell SurvivalCryopreservationHumansInduced Pluripotent Stem CellsMetabolic Networks and PathwaysMitochondriaMyocytes, CardiacUp-RegulationProteins

Identifiers

PMID39809079
PMCPMC11788069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.