Evidence map›Paper›PMID 39808663›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Estimating realized relatedness in free-ranging macaques by inferring identity-by-descent segments.

Annika Freudiger, Vladimir M Jovanovic, Yilei Huang, Noah Snyder-Mackler, Donald F Conrad, Brian Miller, Michael J Montague, Hendrikje Westphal, Peter F Stadler, Stefanie Bley and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Annika Freudiger *Department of Primate Behavioral Ecology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0003-1795-7944
Vladimir M Jovanovic *Department of Biology, Chemistry and Pharmacy, Human Biology and Primate Evolution, Freie Universität Berlin, Berlin 14195, Germany.ORCID 0000-0002-8056-5065
Yilei Huang *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
Noah Snyder-MacklerCenter for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, AZ 85281.ORCID 0000-0003-3026-6160
Donald F ConradDivision of Genetics, Oregon National Primate Research Center, Portland, OR 97006.ORCID 0000-0003-3828-8970
Brian MillerDivision of Genetics, Oregon National Primate Research Center, Portland, OR 97006.
Michael J MontagueDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-0253-4404
Hendrikje WestphalDepartment of Primate Behavioral Ecology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.
Peter F StadlerBioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, Leipzig University, Leipzig 04107, Germany.
Stefanie BleyDepartment of Primate Behavioral Ecology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0007-8227-6826
Julie E HorvathResearch and Collections Section, North Carolina Museum of Natural Sciences, Raleigh, NC 27601.
Lauren J N BrentCentre for Research in Animal Behavior, University of Exeter, Exeter EX4 4QD, United Kingdom.ORCID 0000-0002-1202-1939
Michael L PlattDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-3912-8821
Angelina Ruiz-LambidesCayo Santiago Field Station, Caribbean Primate Research Center, University of Puerto Rico, Punta Santiago 00741, Puerto Rico.
Jenny TungDepartment of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.ORCID 0000-0003-0416-2958
Katja Nowick *Department of Biology, Chemistry and Pharmacy, Human Biology and Primate Evolution, Freie Universität Berlin, Berlin 14195, Germany.
Harald Ringbauer *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.ORCID 0000-0002-4884-9682
Anja Widdig *Department of Primate Behavioral Ecology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0003-1772-8770

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
Multispecies NHP dGTEx Research CenterU24HG012483 · NHGRI · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRISTIN ARDLIE, DONALD F. CONRAD · 2022 to 2026
$17.0M
Coordinating center for collaborative marmoset researchU24MH123696 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI DONALD F. CONRAD · 2020 to 2026
$4.6M
Social modifiers of the pace of aging across multiple domains and tissuesR01AG060931 · NIA · UNIVERSITY OF WASHINGTON · PI BRENT, LAUREN JOHANNA NICOLE, HIGHAM, JAMES P · 2019 to 2023
$3.6M
Animal Model of Genetics and Social Behavior in Autism Spectrum DisordersR01MH096875 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PLATT, MICHAEL L · 2012 to 2016
$3.6M
Neurogenomics of Vulnerability and Resilience to Mental Health Syndromes in Response to Extreme Life EventsR01MH118203 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PLATT, MICHAEL L · 2019 to 2023
$1.9M
Deutsche Forschungsgemeinschaft (DFG) WI 1808/7-1HHS | National Institutes of Health (NIH) R01-AG-060931HHS | National Institutes of Health (NIH) R01-MH-096875HHS | National Institutes of Health (NIH) R01-MH-118203HHS | National Institutes of Health (NIH) U24HG012483HHS | National Institutes of Health (NIH) U24MH123696NHGRI NIH HHS U24 HG012483NIA NIH HHS R01 AG060931NIH HHS P40 OD012217NIH HHS P51 OD011092NIMH NIH HHS R01 MH096875NIMH NIH HHS R01 MH118203NIMH NIH HHS U24 MH123696
6 · The paper itself

Abstract

Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of identical-by-descent DNA segments (IBD) yield the most precise relatedness estimates. Here, we leverage different methods for estimating IBD segments from low-depth whole genome resequencing data to demonstrate the feasibility and value of resolving fine-scaled gradients of relatedness in free-living animals. Using primarily 4 to 6× depth data from a rhesus macaque (

Indexed as

Macaca mulattaAnimalsFemaleGenomeMalePedigreedeep pedigreenonhuman primatesSNP-based relatednessSTR-based relatednessWGS-based relatedness

Identifiers

PMID39808663
PMCPMC11760927

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.