ArticleProceedings of the National Academy of Sciences of the United States of America2025
Specialization of the human hippocampal long axis revisited.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
- Impaired autobiographical remembering and future thinking in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2026Article
- Phylogeny of Cortical-Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions.Hippocampus · 2026Article
- Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making.bioRxiv : the preprint server for biology · 2026Article
- Separate dorsolateral prefrontal cortex regions participate in distinct large-scale networks differentially recruited for social and cognitive control functions.Journal of neurophysiology · 2026Article
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Functional MRI of the Human Hippocampus at 10.5T: Pushing the Boundaries of Spatial Resolution.bioRxiv : the preprint server for biology · 2026Article
- The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.Human brain mapping · 2026Article
- Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- From single scenes to extended scenarios: The role of the ventromedial prefrontal cortex in the construction of imagery-rich events.PloS one · 2026Article
- Article
- Adjacent Dorsolateral Prefrontal Cortex (DLPFC) Regions Participate in Distinct Large-Scale Networks Differentially Recruited for Social and Cognitive Control Functions.bioRxiv : the preprint server for biology · 2025Article
- Verbal versus Nonverbal Processing Leads to Generalized Hemispheric Laterality Effects that Span Multiple Networks.bioRxiv : the preprint server for biology · 2025Article
- Too Little and Too Much: Balanced Hippocampal, But Not Medial Prefrontal, Neural Activity Is Required for Intact Novel Object Recognition in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Graded encoding of spatial novelty scales in the human brain.Nature communications · 2025Article
- Article
- Old-New Recognition Memory Revisited.bioRxiv : the preprint server for biology · 2025Article
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Abstract
The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of the human hippocampal long axis using network-anchored precision functional MRI in two independent datasets (N = 11 and N = 9) paired with behavioral analysis (N = 266 and N = 238). Functional connectivity analyses demonstrated that the anterior hippocampus was preferentially correlated with a cerebral network associated with remembering, while the posterior hippocampus selectively contained a region correlated with a distinct network associated with behavioral salience. Seed regions placed within the hippocampus recapitulated the distinct cerebral networks. Functional characterization of the anterior and posterior hippocampal regions using task data identified and replicated a functional double dissociation. The anterior hippocampal region was sensitive to remembering and imagining the future, specifically tracking the process of scene construction, while the posterior hippocampal region displayed transient responses to targets in an oddball detection task and to transitions between task blocks. These findings suggest an unexpected specialization along the long axis of the human hippocampus with differential responses reflecting the functional properties of the partner cerebral networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.