Evidence map›Paper›PMID 39808660›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA.

Liangzhan Sun, Pengchao Hu, Hui Yang, Jun Ren, Rong Hu, Shasha Wu, Yanchen Wang, Yuyang Du, Jingyi Zheng, Fenfen Wang and 6 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Loss of NCCRP1 overcomes immune evasion in lung adenocarcinoma.Journal for immunotherapy of cancer · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Liangzhan Sun *Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Pengchao Hu *Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Hui YangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Jun RenDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Rong HuDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Shasha WuDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Yanchen WangShenzhen Hospital, Southern Medical University, Shenzhen 518000, China.
Yuyang DuDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Jingyi ZhengShenzhen Hospital, Southern Medical University, Shenzhen 518000, China.
Fenfen WangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Han GaoDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Jingsong YanDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Yun-Fei YuanState Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
Xin-Yuan GuanDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-4485-6017
Jia XiaoGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China.
Yan LiShenzhen Hospital, Southern Medical University, Shenzhen 518000, China.ORCID 0000-0003-1146-5578

Funding

GDSTC | Natural Science Foundation of Guangdong Province () 2022A1515012284MOST | National Natural Science Foundation of China (NSFC) 82073127MOST | National Natural Science Foundation of China (NSFC) 82122009MOST | National Natural Science Foundation of China (NSFC) 82372768| Natural Science Foundation of Shenzhen Municipality (Shenzhen Natural Science Foundation) JCYJ20220530115204011
6 · The paper itself

Abstract

ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 in tumorigenesis remains elusive. We investigated the role of ADARp110 in HCC and underlying mechanisms using clinical samples, a hepatocyte-specific

Indexed as

Carcinoma, HepatocellularCD24 AntigenLiver NeoplasmsRNA-Binding ProteinsRNA, MessengerRNA StabilityAnimalsCell Line, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceTumor MicroenvironmentCD24 AntigenCD24 protein, humanRNA-Binding ProteinsRNA, MessengerADARp110CD24hepatocellular carcinomamacrophagephagocytosis

Identifiers

PMID39808660
PMCPMC11761664

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.