Evidence map›Paper›PMID 39808658›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis.

Samuel Clémot-Dupont, José Alex Lourenço Fernandes, Sarah Larrigan, Xiaoqi Sun, Suma Medisetti, Rory Stanley, Ziyad El Hankouri, Shrilaxmi V Joshi, David J Picketts, Karthik Shekhar and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  11. The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel Clémot-Dupont *Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.
José Alex Lourenço Fernandes *Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.ORCID 0000-0003-2995-5452
Sarah Larrigan *Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.
Xiaoqi Sun *Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.ORCID 0000-0002-1965-8967
Suma MedisettiRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.ORCID 0009-0000-9281-2134
Rory StanleyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.
Ziyad El HankouriRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.ORCID 0000-0002-3155-3287
Shrilaxmi V JoshiRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.ORCID 0000-0002-1996-5561
David J PickettsRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.ORCID 0000-0002-9227-2016
Karthik ShekharDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Pierre MattarRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6.ORCID 0000-0002-5708-6218

Funding

Brain and Behavior Research Foundation (BBRF) 28564Canada Foundation for Innovation (CFI) JELF 37688Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-159619Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-165994Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-166032Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-180577New Frontiers in Research Fund NFRFT-2022-00327Simons Foundation Autism Research Initiative (SFARI) 609562
6 · The paper itself

Abstract

Although chromatin remodelers are among the most important risk genes associated with neurodevelopmental disorders (NDDs), the roles of these complexes during brain development are in many cases unclear. Here, we focused on the recently discovered ChAHP chromatin remodeling complex. The zinc finger and homeodomain transcription factor ADNP is a core subunit of this complex, and de novo

Indexed as

Chromatin Assembly and DisassemblyHomeodomain ProteinsNeocortexNerve Tissue ProteinsNeurodevelopmental DisordersNeurogenesisAnimalsCell ProliferationGene Expression Regulation, DevelopmentalMiceMice, KnockoutNeural Stem CellsNeuronsAdnp protein, mouseHomeodomain ProteinsNerve Tissue ProteinsAdnpChAHP complexchromatin remodelingneocortexneurodevelopmental disorders

Identifiers

PMID39808658
PMCPMC11760920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.