Evidence map›Paper›PMID 39808657›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Tubulin detyrosination shapes

Rosa Milagros Corrales, Jeremy Vincent, Lucien Crobu, Rachel Neish, Binita Nepal, Julien Espeut, Grégoire Pasquier, Ghislain Gillard, Chantal Cazevieille, Jeremy C Mottram and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Expansion Microscopy in Euglenozoa.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
  6. Article
  7. Protein Profiling of Wild-CaughtPathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rosa Milagros CorralesMaladies infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, University of Montpellier, CNRS, Institut de Recherche pour le Développement, Montpellier 34095, France.
Jeremy Vincent *Maladies infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, University of Montpellier, CNRS, Institut de Recherche pour le Développement, Montpellier 34095, France.ORCID 0009-0009-7103-5503
Lucien Crobu *Maladies infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, University of Montpellier, CNRS, Institut de Recherche pour le Développement, Montpellier 34095, France.
Rachel NeishYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0001-9756-546X
Binita NepalDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Julien EspeutTubulin Code team, Institute of Human Genetics, CNRS, Université Montpellier, Montpellier 34090, France.ORCID 0000-0002-0182-033X
Grégoire PasquierMaladies infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, University of Montpellier, CNRS, Institut de Recherche pour le Développement, Montpellier 34095, France.
Ghislain GillardTubulin Code team, Institute of Human Genetics, CNRS, Université Montpellier, Montpellier 34090, France.ORCID 0000-0003-0584-1063
Chantal CazevieilleUniversité Montpellier, INSERM U1298, Institute for Neurosciences of Montpellier, Montpellier 34090, France.
Jeremy C MottramYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0001-5574-3766
Dawn M WetzelDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Yvon SterkersMaladies infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, University of Montpellier, CNRS, Institut de Recherche pour le Développement, Montpellier 34095, France.ORCID 0000-0002-5623-5664
Krzysztof RogowskiTubulin Code team, Institute of Human Genetics, CNRS, Université Montpellier, Montpellier 34090, France.ORCID 0000-0002-0206-3289
Maude F LévêqueMaladies infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, University of Montpellier, CNRS, Institut de Recherche pour le Développement, Montpellier 34095, France.ORCID 0000-0001-9539-9787

Funding

Targeting a New Therapy for TrypanosomatidsR01AI146349 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI WETZEL, DAWN MARIE · 2019 to 2023
$3.0M
Agence Nationale de la Recherche (ANR) ANR-11-LABX-0024-01Agence Nationale de la Recherche (ANR) ANR-21-CE16-0026-01Agence Nationale de la Recherche (ANR) ANR-23-CE15-0022American Heart Association (AHA) NDFondation pour la Recherche Médicale (FRM) ARF202209015774HHS | NIH (NIH) R01AI146359NIAID NIH HHS R01 AI146349Welch Foundation (The Welch Foundation) I-2048Wellcome TrustWellcome Trust (WT) 200807/Z/16/Z
6 · The paper itself

Abstract

Tubulin detyrosination has been implicated in various human disorders and is important for regulating microtubule dynamics. While in most organisms this modification is restricted to α-tubulin, in trypanosomatid parasites, it occurs on both α- and β-tubulin. Here, we show that in

Indexed as

CytoskeletonLeishmaniaTubulinAnimalsFlagellaLeishmaniasisMacrophagesMiceMicrotubulesProtozoan ProteinsVirulenceProtozoan ProteinsTubulindynamicskinesin-13microtubulestrypanosomatidsvasohibin

Identifiers

PMID39808657
PMCPMC11761321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.