Evidence map›Paper›PMID 39808367›Full record

ReviewHeart failure reviews2025

Advanced Markers for Hemodynamic Monitoring in Cardiogenic Shock and End-Stage Heart Failure: A Mini Review.

Konstantinos Sideris, Christos P Kyriakopoulos, Lina Brinker, Iosif Taleb, Sotiria Liori, Aliya Hutman-Zahler, Nicholas Hendren, Eric Hall, Stavros G Drakos, Josef Stehlik and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Konstantinos SiderisDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Christos P KyriakopoulosDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Lina BrinkerDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Iosif TalebDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Sotiria LioriDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Aliya Hutman-ZahlerDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Nicholas HendrenDivision of Cardiovascular Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Eric HallDivision of Cardiovascular Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Stavros G DrakosDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Josef StehlikDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
James C FangDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Mark H DraznerDivision of Cardiovascular Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Spencer CarterDivision of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA. spencer.carter@hsc.utah.edu.

Funding

NHLBI NIH HHS 2T32HL007576-36
6 · The paper itself

Abstract

Right heart catheterization (RHC) provides critical hemodynamic insights by measuring atrial, ventricular, and pulmonary artery pressures, as well as cardiac output (CO). Although the use of RHC has decreased, its application has been linked to improved outcomes. Advanced hemodynamic markers such as cardiac power output (CPO), aortic pulsatility index (API), pulmonary artery pulsatility index (PAPi), right atrial pressure to pulmonary capillary wedge pressure ratio (RAP/PCWP) and right ventricular stroke work index (RVSWI) have been introduced to enhance risk stratification in cardiogenic shock (CS) and end-stage heart failure (HF) patients. CPO has emerged as a potent prognostic tool, with values below 0.6 Watts significantly associated with mortality. Similarly, API and PAPi have demonstrated strong predictive power for adverse outcomes, including death and the need for advanced HF therapies. RAP/PCWP ratio is shown to be a valuable a prognostic tool for RV dysfunction, mortality, and adverse outcomes. Despite mixed evidence on the prognostic utility of RVSWI, its physiologic relevance in assessing right ventricular function remains important. A novel clinical observation, involving patients with an RAP numerically greater than pulmonary artery saturation, was associated with a 71% 30-day mortality rate, underscoring the potential prognostic value of this finding. This review aims to summarize key advanced hemodynamic markers and their role in improving risk stratification and guiding treatment in CS and end-stage HF. The integration of these markers into clinical practice holds the potential to enhance personalized care and improve outcomes for patients with CS and advanced HF.

Indexed as

Heart FailureHemodynamic MonitoringHemodynamicsShock, CardiogenicVentricular Function, RightCardiac CatheterizationCardiac OutputHumansPrognosisPulmonary Wedge PressureAortic Pulsatility IndexCardiac Power OutputCardiogenic ShockPulmonary Artery Pulsatility IndexRight Atrial Pressure to Pulmonary Capillary Wedge Pressure RatioRight Ventricular Stroke Work Index

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.