Evidence map›Paper›PMID 39808347›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Multiple sclerosis and sickle cell anemia: when two worlds collide.

Matteo Betti, Cristina Giubbilei, Simona D'angelo, Emilio Portaccio, Maria Pia Amato, Valentina Carrai

Abstract readCase Reports
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matteo BettiDepartment of NEUROFARBA, University of Florence, Section of Neurology, Largo Brambilla 3, Florence, 50134, Italy. matteo.betti@unifi.it.ORCID http://orcid.org/0000-0001-6621-3971
Cristina GiubbileiHematology Unit, Careggi University Hospital, Florence, Italy.
Simona D'angeloHematology Unit, Careggi University Hospital, Florence, Italy.
Emilio PortaccioDepartment of NEUROFARBA, University of Florence, Section of Neurology, Largo Brambilla 3, Florence, 50134, Italy.
Maria Pia AmatoDepartment of NEUROFARBA, University of Florence, Section of Neurology, Largo Brambilla 3, Florence, 50134, Italy.
Valentina CarraiHematology Unit, Careggi University Hospital, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coexistence of sickle cell anemia and multiple sclerosis in a single patient presents a rare and challenging clinical scenario, possibly favoured by the interplay between chronic inflammatory states and autoimmune processes. METHOS/

resultsWe present the case of a 36-year-old woman with sickle cell anemia who developed progressive neurological symptoms leading to frequent falls and paraparesis; magnetic resonance imaging showed many periventricular, infratentorial, and both cervical and dorsal spinal cord lesions, leading to a diagnosis of multiple sclerosis. After a multidisciplinary approach the patient was successfully started on ofatumumab.

conclusionThis case report raises awareness among clinicians to consider the possibility of multiple sclerosis in patients with sickle cell anemia who present with neurological symptoms, ensuring timely diagnosis and intervention, and emphasizes the need for a personalized, multidisciplinary approach to care.

Indexed as

Anemia, Sickle CellMultiple SclerosisAdultFemaleHumansMagnetic Resonance ImagingAnti-CD20AutoimmunityComorbidityMultiple sclerosisSickle cell anemia

Identifiers

PMID39808347

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.