Evidence map›Paper›PMID 39808249›Full record

ArticleJournal of gastrointestinal cancer2025

Timing of Surgery and Postoperative Outcomes in Esophagectomy for Squamous Cell Carcinoma: A Prospective Study in North India.

Lovepreet Singh, Cherring Tandup, Manish Thakur, Aravind Sekar, Jayanta Samanta, Satish Subbiah Nagaraj, Swapnesh Kumar Sahu, Yashwant Sakaray, R N Naga Santosh, Kailash Kurdia and 1 more

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Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Lovepreet SinghGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India.
Cherring TandupGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India. ctandup@gmail.com.
Manish ThakurGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India.
Aravind SekarPathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Jayanta SamantaGastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Satish Subbiah NagarajGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India.
Swapnesh Kumar SahuGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India.
Yashwant SakarayGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India.
R N Naga SantoshGeneral Surgery, Post Graduate Institute of Medical Education and Research, Room No. 26 Nehru Hospital, Chandigarh, India.
Kailash KurdiaSurgical Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Vipul ThakurMM Medical College Sadopur, Haryana, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeoadjuvant chemotherapy followed by esophagectomy is the usual approach to manage esophageal squamous cell carcinoma (ESCC). The optimal interval to operate after completion of neoadjuvant chemoradiotherapy (NACRT) still remains controversial.

methodsA prospective study was conducted to observe and compare postoperative complications and pathological outcomes in patients with squamous cell carcinoma of the esophagus who underwent NACRT followed by surgery within 8 weeks or after 8 weeks of NACRT completion. The pathological complete response was assessed using the Mandard tumor regression grade. Morbidity and mortality were compared and were graded using the Clavien-Dindo scale.

resultsThe study included 50 patients, 19 patients in the < 8-week group and 31 in the > 8-week group study. Patients underwent thoracoscopy-assisted esophagectomy with neoesophagus formation using gastric conduit. There was a significant difference in mortality between the two groups, with three mortalities in the < 8-week group and none in the other group (p = 0.022). Postoperative complications and pathological outcomes did not have a statistically significant difference between the two groups.

conclusionThe pathological response in ESCC cases does not appear to be impacted by the interval between NACRT and surgery; nevertheless, early surgery was associated with a higher risk of mortality.

Indexed as

Carcinoma, Squamous CellEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyPostoperative ComplicationsAdultAgedChemoradiotherapy, AdjuvantFemaleHumansIndiaMaleMiddle AgedNeoadjuvant TherapyProspective StudiesTime FactorsChylothoraxConduit necrosisEsophageal squamous cell carcinomaPathological complete responseTumor regression grading

Identifiers

PMID39808249

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