ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025
Prostate motion in magnetic resonance imaging-guided radiotherapy and its impact on margins.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Intra-adaptational motion during online adaptive radiotherapy: analysis of couch shifts and implications for margin design.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Improving workflow efficiency during prostate stereotactic body radiotherapy using real-time adaptive planning associated with reduced intra-fractional target motion.Radiation oncology (London, England) · 2026Article
- Impact of intra- and interfractional motion on the dose distribution and urinary adverse events for magnetic resonance-guided prostate cancer radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Clinical experience with an online adaptive radiotherapy for prostate cancer: successful treatment time optimization.BMC cancer · 2026Article
- Cone-beam CT-based estimations of prostate motion and dose distortion during radiotherapy.Physics and imaging in radiation oncology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study focused on reducing the margin for prostate cancer treatment using magnetic resonance imaging-guided radiotherapy by investigating the intrafractional motion of the prostate and different motion-mitigation strategies.
methodsWe retrospectively analyzed intrafractional prostate motion in 77 patients with low- to intermediate-risk prostate cancer treated with five fractions of 7.25 Gy on a 1.5 T magnetic resonance linear accelerator. Systematic drift motion was observed and described by an intrafractional motion model. The planning target volume (PTV) margin was calculated in a cohort of 77 patients and prospectively evaluated for geometric coverage in a separate cohort of 24 patients.
resultsThe intrafractional model showed that the prostate position starts out of equilibrium for the anterior-posterior (-1.8 ± 3.1 mm) and superior-inferior (1.7 ± 2.6 mm) directions, with relaxation times of 12 and 15 min, respectively. Position verification scans are acquired at 30 min on average. At that time, the transient drift motion becomes indistinguishable from the residual random intrafractional motion. PTV margins can be reduced to 1.8 mm (left-right), 3.2 mm (anterior-posterior), and 2.9 mm (superior-inferior). Evaluation of the overlap with the clinical target volume (CTV) was performed for a total of 120 fractions of 24 patients. The overlap range between the CTV and the PTV was 93-100% and the applied 3‑mm PTV margin for the CTV had a 99.5% averaged geometric overlap for all patients.
conclusionA PTV margin reduction to 3 mm is feasible. A patient-specific approach could reduce the margins further.
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