ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
A Neighborhood-Level Hispanic Paradox: The Interaction among Hispanic Density, Neighborhood Disadvantage, and Survival in Patients with Breast Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Racial and ethnic disparities in esophageal cancer survival are greatest at curable stages: a population-based study.Cancer causes & control : CCC · 2026Article
- Impact of Neighborhood Disadvantage on Youth Emotional Symptoms and Transdiagnostic Cognitive-Behavioral Treatment Outcomes.Child psychiatry and human development · 2025Article
- Advancing health psychology research in oncology: Biobehavioral models, stress pathways, and stress-management interventions for cancer patients.International journal of clinical and health psychology : IJCHPArticle
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7 authors.
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Abstract
backgroundTo evaluate the impact of Hispanic ethnic enclaves (EE) on the relationship between neighborhood disadvantage and overall survival in patients with breast cancer.
methodsData from patients with stage I to IV breast cancer diagnosed between 2005 and 2017 were used to analyze the effects of area deprivation index (ADI) scores, a measure of neighborhood disadvantage, and census tract-level Hispanic density, a measure of EE, on overall survival using mixed-effects Cox regression models. The final model included the individual-level factors [age, income, race, Hispanic/Latino origin, nativity, insurance status, and comorbidities (hypertension, diabetes, and body mass index)] and clinical factors (National Comprehensive Cancer Network guideline-concordant treatment, stage, and receptor subtype).
resultsA total of 5,387 patients were analyzed. Fifty-two percent resided in Hispanic EE. Enclave residents were predominantly White (93%), with Cubans the predominant subgroup (37%). Overall, there were 1,040 deaths within the cohort. Patients residing in highly disadvantaged neighborhoods (ADI tertile 3) within Hispanic EE experienced reduced HR compared with those outside of EE, evidenced by the interaction effect {EE × ADI tertile 3 - HR [95% confidence interval (CI)], 0.66 (0.44-0.98)}.
conclusionsHispanic EE may protect against mortality in patients with breast cancer, suggesting that positive social factors help combat negative effects of neighborhood disadvantage for patients. Understanding the protective attributes of EE can help create effective cancer interventions and promote more equitable outcomes in minority populations. IMPACT: This study found that EE may protect against mortality in patients with breast cancer, suggesting that positive social factors may help mitigate the negative effects caused by the neighborhood.
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