ArticleAnimal models and experimental medicine2025
A mouse coccygeal intervertebral disc degeneration model with tail-looping constructed using a suturing method.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mechanical stress-mediated ferritinophagy aggravates cartilage endplate degeneration via a PIEZO1-NCOA4-ZBP1 axis.Autophagy · 2026Article
- Article
- Compression suture: A method for simulating intervertebral disc degeneration in rats induced by excessive loading.Animal models and experimental medicine · 2026Article
- Injury Induces More Severe Biomechanical Changes in Middle-Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model.JOR spine · 2025Article
- What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain.Bone research · 2025Review
- A mouse coccygeal intervertebral disc degeneration model with tail-looping constructed using a suturing method.Animal models and experimental medicine · 2025Article
- Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside.Pharmaceutics · 2025Review
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12 authors.
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Abstract
backgroudIntervertebral disc degeneration (IDD) is one of the common degenerative diseases. Due to ethical constraints, it is difficult to obtain sufficient research on humans, so the use of an animal model of IDD is very important to clarify the pathogenesis and treatment mechanism of the disease.
methodsIn this study, thirty 2-month-old mice were selected for operation to establish a coccygeal IDD model. The distal tail portion of the tail (beyond the 17th coccygeal vertebra) and a small piece of skin above the 8th coccygeal vertebra were excised, and the two incisions were brought together after flexion, and secured with sutures. The heights and signal intensities of the intervertebral discs (IVDs) were assessed using microcomputed tomography (μCT) and magnetic resonance imaging (MRI) at 0, 6, 12 weeks postoperatively. The overall tissue morphology, cell distribution and density, and extracellular matrix of the IVDs were also assessed using Hematoxylin and Eosin (HE), Safranin O-Fast Green and immunohistochemical staining.
resultsAll mice in the experimental group survived after the operation, and there were no complications such as wound infection, tail necrosis and suture shedding. The experimental results demonstrated that the suturing method can successfully initiate IDD. Different severity levels of IDD can be induced by controlling the bending angle of the IVDs within the tail loop; however, for consistency, histologic and imaging results should be obtained at the same bending angle and looping period.
conclusionsThis IDD model is an effective method for studying the etiology and treatment of degenerative IVD disease.
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