Evidence map›Paper›PMID 39807861›Full record

ArticlemBio2025

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens.

Karthik Hullahalli, Katherine G Dailey, Ryan Acbay, Masataka Suzuki, George I Balazs, Matthew K Waldor

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karthik HullahalliDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-3064-2090
Katherine G DaileyDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0004-7013-0932
Ryan AcbayDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
Masataka SuzukiDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
George I BalazsDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
Matthew K WaldorDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1843-7000

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Center for Integrated Solutions in Infectious DiseasesHHS | National Institutes of Health (NIH) R01AI042347Howard Hughes Medical Institute (HHMI)NIAID NIH HHS R01 AI042347
6 · The paper itself

Abstract

Bacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic

Indexed as

Anti-Inflammatory AgentsEscherichia coli InfectionsInflammationReverse Transcriptase InhibitorsAnimalsCytokinesDisease Models, AnimalEscherichia coliImmunity, InnateLipopolysaccharidesLiverMiceMice, Inbred C57BLStaphylococcus aureusAnti-Inflammatory AgentsCytokinesLipopolysaccharidesReverse Transcriptase Inhibitorsinflammationreverse transcriptase inhibitorssepsis

Identifiers

PMID39807861
PMCPMC11796363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.