ArticleImmunity, inflammation and disease2025
The Relationship Between Novel Inflammatory Markers and Serum 25-Hydroxyvitamin D Among US Adults.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association Between the Uric Acid-to-Creatinine Ratio and Elevated Parathyroid Hormone Levels in Adults Without Known Parathyroid Disease.Journal of clinical medicine · 2026Article
- Relation of Serum Vitamin-D Level with Serum Interleukin-6 and Interleukin-10 in Patients with Primary Osteoarthritis of Knee.Journal of orthopaedic case reports · 2025Article
- Association of platelet-to-high-density lipoprotein cholesterol ratio and its cumulative exposure with cardiovascular disease risk: a prospective cohort study in Chinese population.Frontiers in cardiovascular medicine · 2025Article
- 25-(OH)D Deficiency and the Risk of Minor Amputation in Patients with Diabetes Foot Ulcers: A Chinese Cohort Study.International journal of general medicine · 2025Article
- Association between serum 25-hydroxyvitamin D concentrations and platelet to high-density lipoprotein cholesterol ratio: evidence from two population-based studies.Frontiers in nutrition · 2025Article
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6 authors.
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Abstract
backgroundVitamin D is the focus of extensive medical research globally. Recent studies have investigated the correlation between serum 25-hydroxyvitamin D (25(OH)D) and common inflammatory markers. However, few studies have incorporated novel inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), platelet-to-high density lipoprotein cholesterol ratio (PHR), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response (SIRI), and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR). This study investigated these correlations among adults in the USA.
methodsWe ultimately included a total of 5308 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning 2007 to 2018. A multivariable linear regression model assessed the links between serum 25(OH)D and these novel inflammatory markers, with subgroup analyses for hypertension and diabetes. To further explore the relationship between the two, we applied smooth curve fittings and generalized additive models. Upon detecting nonlinear relationships, we used a recursive algorithm to pinpoint the inflection point.
resultsIn our multivariate linear regression model, serum 25(OH)D concentrations were negatively correlated with NHR (β = -0.003, 95% CI: -0.005 to -0.001), NLR (β = -0.002, 95% CI: -0.003 to 0.000), SII (β = -0.579, 95% CI: -0.954 to -0.205), PHR (β = -0.171, 95% CI: -0.249 to -0.093), and PLR (β = -0.096, 95% CI: -0.051 to -0.040) among adults in the USA. Nevertheless, no significant association was found with SIRI (β = -0.001, 95% CI: -0.002 to 0.000). Subgroup analysis by hypertension and diabetes showed that in the hypertensive group, serum 25(OH)D was significantly and negatively associated with NHR, NLR, SII, SIRI, PHR, and PLR. However, no correlation was found in the diabetic group between serum 25(OH)D levels and these inflammatory markers.
conclusionsOur research confirms that serum 25(OH)D levels are negatively correlated with several novel inflammatory markers among adults in the USA, suggesting potential directions for further research into vitamin D's role in inflammation.
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