SynthesisJournal of cosmetic dermatology2025
The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis.
Synthesis in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regenerative Approaches in Vulvar Lichen Sclerosus: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Comparing the Cutaneous Impacts of a Topical Restructuring Serum versus. Injected Hyaluronic Acid (HA) and Their Combination as Potential Anti-Aging Strategies in Chinese Women: An In Vivo Study.Dermatology and therapy · 2026Article
- Standalone Intra-Articular Injections for Temporomandibular Joint Disorders: Overview of Meta-Analytic Evidence.Journal of clinical medicine · 2026Review
- Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study.Plastic and reconstructive surgery. Global open · 2026Article
- An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy.Journal of functional biomaterials · 2026Article
- Correlational and Molecular Mechanism Analyses of Bioactive Compounds FromFood science & nutrition · 2026Article
- Hyaluronic Acid ProfhiloMedicina (Kaunas, Lithuania) · 2026Article
- Synergistic protective and regenerative effects of hyaluronic acid and polynucleotides against UVA-induced oxidative stress in dermal fibroblasts.Scientific reports · 2026Article
- Short- and Long-Term Patient Perceptions Relative to Hyaluronic Acid Filler Volume Retention.Aesthetic surgery journal. Open forum · 2026Article
- Remodeling Effect of HA Hybrid Cooperative Complexes on Dermal White Adipose Tissue and Its Structure.Clinical, cosmetic and investigational dermatology · 2026Article
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
- Efficacy and Safety of Hyaluronic Acid Fillers for Horizontal Neck Lines: A Systematic Review and Meta-Analysis.Aesthetic surgery journal. Open forum · 2026Review
- Integrative Aesthetics: Shaping the Emerging Frontier of Modern Aesthetic Medicine.Clinical, cosmetic and investigational dermatology · 2026Review
- Safety and Efficacy of Hyaluronic Acid-Based Filler for Neck Wrinkles: A Prospective, Multicenter, Randomized, Parallel-Controlled Non-Inferiority Trial.Clinical, cosmetic and investigational dermatology · 2026Article
- Advances in Anti-aging Procedures: A Comprehensive Review of Surgical and Non-surgical Rejuvenation Techniques.Cureus · 2025Review
- Effect of hyaluronic acid dermal fillers for mid-face volume enhancement: A systematic review and meta-analysis.Bioinformation · 2025Article
- Modulating rheology and bioactivity in dermal fillers: the emerging role of platelet-rich plasma (PRP).Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging reduces the production of hyaluronic acid (HA) in the skin, leading to wrinkles and sagging. HA-based skincare products are being studied to improve skin quality. This systematic review and meta-analysis aimed to compare the effectiveness of HA-based injectable products for reducing wrinkles and enhancing skin elasticity, hydration, and radiation.
methodsEligible trial reports were found by searching PubMed, Embase, Scopus, and Web of Science systematically until May 2024. A random-effects meta-analysis was performed to evaluate the effect of HA injection on skin aging. The protocol of the study has been registered in PROSPERO with a registration ID of CRD42024540703.
resultsOverall, 12 studies met the inclusion criteria, of which 6 studies had enough data for meta-analysis. The random-effect meta-analysis showed improved hydration (SMD = 1.34, 95% CI = 0.14-2.54, and p < 0.05) and radiance (SMD = 0.51, 95% CI = 0.22-0.80, and p < 0.05) after HA filler injection. However, there was no significant difference in elasticity (SMD = 0.25, 95% CI = -0.20-0.70, and p = 0.27) and melanin index (SMD = -1.74, 95% CI = -4.89-1.41, p = 0.28) compared to controls.
conclusionsAccording to the results of a meta-analysis, hyaluronic acid injections have been found to improve skin hydration and radiance, thus reversing the effects of skin aging. However, the study did not find any significant changes in the skin's elasticity or melanin index. Further research is required to confirm the effectiveness of hyaluronic acid in treating skin aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.