Evidence map›Paper›PMID 39807595›Full record

ArticleCirculation. Cardiovascular quality and outcomes2025

Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy.

Natalie A Cameron, Xiaoning Huang, Lucia C Petito, Hongyan Ning, Nilay S Shah, Lynn M Yee, Amanda M Perak, David M Haas, Brian M Mercer, Samuel Parry and 11 more

Abstract readComparative Study
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Tailoring cardiovascular risk prediction to females.The Journal of endocrinology · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Natalie A CameronDivision of General Internal Medicine, Department of Medicine (N.A.C.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-0613-7580
Xiaoning HuangDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0001-5813-5993
Lucia C PetitoDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-0156-1219
Hongyan NingDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-1157-6614
Nilay S ShahDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-3519-8662
Lynn M YeeDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology (L.M.Y.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-6274-0544
Amanda M PerakDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-1025-0997
David M HaasDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis (D.M.H.).ORCID 0000-0002-8379-0743
Brian M MercerDepartment of Obstetrics and Gynecology, Case Western Reserve University School of Medicine, Cleveland, OH (B.M.M.).
Samuel ParryDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia (S.P.).ORCID 0000-0002-5946-9247
George R SaadeDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston (G.R.S.).ORCID 0000-0001-7925-5302
Robert M SilverDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City (R.M.S.).
Hyagriv N SimhanDepartment of Obstetrics and Gynecology, Magee-Women's Research Institute & Foundation, University of Pittsburgh School of Medicine, PA (H.N.S.).
Uma M ReddyDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY (U.M.R.).
Jasmina VaragicNational Heart, Lung, and Blood Institute, Bethesda, MD (J.V.).
Ernesto LiconDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California Irvine School of Medicine (E.L.).
Philip GreenlandDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-6327-2439
Donald M Lloyd-JonesDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-0847-6110
Kiarri N KershawDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-0063-6397
William A GrobmanDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus (W.A.G.).
Sadiya S KhanDepartment of Preventive Medicine (N.A.C., X.H., L.C.P., H.N., N.S.S., A.M.P., P.G., D.M.L.-J., K.N.K., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-0643-1859

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Stress and Racial Disparities in Preeclampsia - Clues from DNA Methylomic ProfilingU01HL145358 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI Philip Greenland, Rebecca Boehm McNeil · 2020 to 2026
$24.6M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063036 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2010 to 2015
$19.5M
Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes Supplement RequestU10HL119991 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2013 to 2018
$12.6M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI JAIN, MOHIT · 2020 to 2024
$8.7M
Whole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3M
PRegnancy OuTcomEs and subclinical Cardiovascular disease sTudy: (PROTECT)R01HL161514 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sadiya Sana Khan · 2022 to 2026
$3.3M
Prevention of Preterm Birth in high Risk Nulliparous PatientsU10HD063047 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2010 to 2014
$1.9M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001108NCATS NIH HHS UM1 TR004528NHLBI NIH HHS R01 HL124649NHLBI NIH HHS R01 HL161514NHLBI NIH HHS U01 HL145358NHLBI NIH HHS U10 HL119989NHLBI NIH HHS U10 HL119990NHLBI NIH HHS U10 HL119991NHLBI NIH HHS U10 HL119992NHLBI NIH HHS U10 HL119993NHLBI NIH HHS U10 HL120006NHLBI NIH HHS U10 HL120018NHLBI NIH HHS U10 HL120019NHLBI NIH HHS U10 HL120034NIA NIH HHS U54 AG065141NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063036NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063041NICHD NIH HHS U10 HD063046NICHD NIH HHS U10 HD063047NICHD NIH HHS U10 HD063048NICHD NIH HHS U10 HD063053NICHD NIH HHS U10 HD063072
6 · The paper itself

Abstract

backgroundSuboptimal cardiovascular health (CVH) in pregnancy is associated with adverse maternal and offspring outcomes. To guide public health efforts to reduce disparities in maternal CVH, we determined the contribution of individual- and neighborhood-level factors to racial and ethnic differences in early pregnancy CVH.

methodsWe included nulliparous individuals with singleton pregnancies who self-identified as Hispanic, non-Hispanic Black (NHB), or non-Hispanic White (NHW) and participated in the nuMoM2b cohort study (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be). First-trimester CVH was quantified using 6 routinely assessed factors in pregnancy included in the American Heart Association Life's Essential 8 score (0-100 points), in which higher scores indicate better CVH. Oaxaca-Blinder decomposition evaluated the extent to which racial and ethnic differences in CVH were explained by differences in individual- and neighborhood-level factors (age, socioeconomic characteristics, psychosocial factors, nativity, perceived racial discrimination, and area deprivation index).

resultsAmong 9104 participants, the mean age was 26.8 years, 18.7% identified as Hispanic, 15.6% identified as NHB, and 65.8% identified as NHW. Mean (SD) CVH scores were 76.7 (14.1), 69.8 (15.1), and 79.9 (14.3) in the Hispanic, NHB, and NHW groups, respectively (

conclusionsRacial and ethnic differences in early pregnancy CVH were largely explained by differences in individual- and neighborhood-level factors.

Indexed as

Cardiovascular DiseasesHealth Status DisparitiesMaternal HealthSocial Determinants of HealthAdultBlack or African AmericanFemaleHeart Disease Risk FactorsHispanic or LatinoHumansPregnancyPregnancy Trimester, FirstRace FactorsResidence CharacteristicsRisk AssessmentRisk Factorsblood pressurebody mass indexethnicityhealth equitysocial determinants of health

Identifiers

PMID39807595
PMCPMC11919558

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