Evidence map›Paper›PMID 39807344›Full record

ArticlePNAS nexus2025

Discovering genetic modulators of the protein homeostasis system through multilevel analysis.

Vishal Sarsani, Berent Aldikacti, Tingting Zhao, Shai He, Peter Chien, Patrick Flaherty

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Vishal SarsaniDepartment of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, MA 01002, USA.ORCID https://orcid.org/0000-0002-9272-3438
Berent AldikactiDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01002, USA.ORCID https://orcid.org/0000-0002-8916-8007
Tingting ZhaoCollege of Business, University of Rhode Island, Kingston, RI 02881, USA.ORCID https://orcid.org/0000-0001-6418-699X
Shai HeDepartment of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, MA 01002, USA.
Peter ChienDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01002, USA.ORCID https://orcid.org/0000-0001-6733-1478
Patrick FlahertyDepartment of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, MA 01002, USA.ORCID https://orcid.org/0000-0001-6097-6572

Funding

Regulated Proteolysisin Bacteria Development and Stress ResponseR35GM130320 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Peter Chien · 2019 to 2026
$3.4M
Learning Conditionally Essential Genetic Networks in the Protein Homeostasis System R01GM135931 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI FLAHERTY, PATRICK · 2019 to 2021
$693k
NIGMS NIH HHS R01 GM135931NIGMS NIH HHS R35 GM130320
6 · The paper itself

Abstract

Every protein progresses through a natural lifecycle from birth to maturation to death; this process is coordinated by the protein homeostasis system. Environmental or physiological conditions trigger pathways that maintain the homeostasis of the proteome. An open question is how these pathways are modulated to respond to the many stresses that an organism encounters during its lifetime. To address this question, we tested how the fitness landscape changes in response to environmental and genetic perturbations using directed and massively parallel transposon mutagenesis in

Indexed as

conditionally essential networksfitnessproteotoxic stresstransposon mutagenesis

Identifiers

PMID39807344
PMCPMC11725641

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.