Evidence map›Paper›PMID 39807180›Full record

ArticleMaterials today. Bio2025

Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy.

Zekai Cui, Xiaoxue Li, Yiwen Ou, Xihao Sun, Jianing Gu, Chengcheng Ding, Zhexiong Yu, Yonglong Guo, Yuqin Liang, Shengru Mao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zekai CuiAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Xiaoxue LiAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Yiwen OuAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Xihao SunAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Jianing GuAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Chengcheng DingAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Zhexiong YuTianren Goji Biotechnology Co., Ltd, Ningxia, China.
Yonglong GuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yuqin LiangAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Shengru MaoAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Jacey Hongjie MaAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Hon Fai ChanInstitute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Shibo TangAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Jiansu ChenAier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic keratopathy (DK), a significant complication of diabetes, often leads to corneal damage and vision impairment. Effective models are essential for studying DK pathogenesis and evaluating potential therapeutic interventions. This study developed a novel biomimetic full-thickness corneal model for the first time, incorporating corneal epithelial cells, stromal cells, endothelial cells, and nerves to simulate DK conditions

Indexed as

Biomimetic full-thickness corneal modelC-C motif chemokine ligand 5 (CCL5)Diabetic keratopathy (DK)Lycium barbarum glycopeptide (LBGP)

Identifiers

PMID39807180
PMCPMC11729032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.