Evidence map›Paper›PMID 39807020›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2025

[Pachymic acid promotes brown/beige adipocyte differentiation and lipid metabolism in preadipocytes].

Kunling Chen, Xiaobing Dou, Yiyou Lin, Danyao Bai, Yangzhou Luo, Liping Zhou

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kunling ChenSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China. chenkunling1997@163.com.
Xiaobing DouSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yiyou LinSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Danyao BaiSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yangzhou LuoSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Liping ZhouSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China. lipingzhou@zcmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effect of pachymic acid on brown/beige adipocyte differentiation and lipid metabolism in preadipocytes.

methods3T3-L1 MBX cells were induced to differentiate into beige adipocytes using a brown cocktail method. The impact of pachymic acid on the viability of 3T3-L1 MBX cells was evaluated using the CCK-8 assay. The formation of lipid droplets following treatment with pachymic acid was observed by oil red O staining. The mRNA expression levels of key browning genes, including uncoupling protein (Ucp) 1, the peroxisome proliferator activated receptor-γ coactivator (Pgc)-1α, and the PR domain-containing protein 16 (Prdm16), as well as the mRNA expression of sterol regulatory element-binding protein (Srebp) 1c, acetyl-coA carboxylase (Acc), fatty acid synthase (Fas), and hormone-sensitive triglyceride lipase (Hsl), adipose triglyceride lipase (Atgl), and carnitine palmitoyltransferase (Cpt) 1 were detected by quantitative reverse transcription polymerase chain reaction. The protein expression of Ucp1, Pgc-1a, and Prdm16 was detected by Western blotting.

resultsThe 3T3-L1 MBX cells were induced

conclusionsPachymic acid can inhibit fat synthesis and promote lipid decomposition by regulating the brown formation and lipid differentiation of preadipocytes.

Indexed as

Adipocytes, BeigeAdipocytes, BrownCell DifferentiationLipid MetabolismTriterpenes3T3-L1 CellsAnimalsMicePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSterol Regulatory Element Binding Protein 1Uncoupling Protein 1pachymic acidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSterol Regulatory Element Binding Protein 1TriterpenesUcp1 protein, mouseUncoupling Protein 13T3-L1 MBX cellsAdipocyte browningLipid metabolismLipogenic differentiationPachymic acid

Identifiers

PMID39807020
PMCPMC12176541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.