Evidence map›Paper›PMID 39806941›Full record

ArticleExperimental neurobiology2024

The Multi-targeted Effect of Fascaplysin on the Proliferation and Dedifferentiation of Schwann Cells Inhibits Peripheral Nerve Degeneration by Blocking CDK4/6 and Androgen Receptor.

Hyung-Joo Chung, Ja-Eun Kim, Youngbuhm Huh, Jin San Lee, So-Woon Kim, Kiyong Na, Jiwon Kim, Seung Hyeun Lee, Hiroyuki Konishi, Seung Geun Yeo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hyung-Joo ChungDepartment of Anesthesiology and Pain Medicine, Kosin University, College of Medicine, Busan 49267, Korea.
Ja-Eun KimDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Youngbuhm HuhDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Jin San LeeDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
So-Woon KimDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Kiyong NaDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Jiwon KimDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Seung Hyeun LeeDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Hiroyuki KonishiDivision of Neuroanatomy, Department of Neuroscience,Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Seung Geun YeoDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Dong Keon YonDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Dokyoung KimDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Junyang JungDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Na Young JeongDepartment of Anatomy and Cell Biology, Dong-A University, College of Medicine, Busan 49201, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral neurodegenerative diseases induced by irreversible peripheral nerve degeneration (PND), such as diabetic peripheral neuropathy, have a high prevalence worldwide and reduce the quality of life. However, there is no agent effective against the irreversible PND. After peripheral nerve injury, Schwann cells play an important role in regulating PND. However, because PND involves multiple biochemical events in Schwann cells, a one-drug-single-target therapeutic strategy is not feasible for PND. Here, we suggested that fascaplysin (Fas), a compound with multiple targets (CDK4/6), could overcome these problems. Fas exerted a significant inhibitory effect on axonal degradation, demyelination, and Schwann cell proliferation and dedifferentiation during

Indexed as

Androgen receptorCDK4/6FascaplysinMulti-target drugPeripheral nerve degenerationSchwann cells

Identifiers

PMID39806941
PMCPMC11738473

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.