Evidence map›Paper›PMID 39806919›Full record

ReviewJournal of biomedical materials research. Part A2025

Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering.

Jinyoung Park, Gulsah Erel Akbaba, Nidhi Sharma, Ritopa Das, Tra Vinikoor, Yang Liu, Duong Quang Le, Kishan Angadi, Thanh Duc Nguyen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biomedical materials research. Part A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
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  7. Article
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  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinyoung ParkDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0003-0943-3649
Gulsah Erel AkbabaInstitute of Materials Science, Polymer Program, University of Connecticut, Storrs, Connecticut, USA.
Nidhi SharmaDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Ritopa DasDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Tra VinikoorDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Yang LiuDepartment of Mechanical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Duong Quang LeDepartment of Mechanical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Kishan AngadiDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Thanh Duc NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0003-0813-4807

Funding

Biodegradable Piezoelectric Nanocomposite Scaffold with Physical Exercise to Heal Major Cartilage Defects in Large AnimalsR01AR080102 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI Thanh Nguyen · 2022 to 2026
$1.9M
Novel Piezoelectric Amino-acid Ultrasound Transducer to Deliver Drugs Through the Blood Brain BarrierR01NS131310 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI Thanh Nguyen · 2023 to 2026
$1.8M
Bionic Self-Charged Bone Composite ScaffoldR01EB036011 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI Wai Hong Lo, Thanh Nguyen · 2024 to 2026
$1.6M
Real-time Measurement of Joint-loading for Osteoarthritis Study and Treatment R21AR078744R21AR078744 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2021 to 2022
$498k
The Molecular Mechanism of the Surface Charge of Piezoelectric Materials for Bone Regenerative EngineeringR21AR075133 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LO, WAI HONG · 2020 to 2021
$402k
Biodegradable Piezoelectric Scaffold for Bone regenerationR21AR075196 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2019 to 2020
$389k
NIAMS NIH HHS R01 AR080102NIAMS NIH HHS R21 AR075133NIAMS NIH HHS R21 AR075196NIAMS NIH HHS R21 AR078744NIBIB NIH HHS R01 EB036011NIH HHS R01AR080102NIH HHS R01EB036011NIH HHS R01NS131310NIH HHS R21AR075133NIH HHS R21AR075196NIH HHS R21AR078744NINDS NIH HHS R01 NS131310
6 · The paper itself

Abstract

In the human body, bioelectric cues are crucial for tissue stimulation and regeneration. Electrical stimulation (ES) significantly enhances the regeneration of nerves, bones, cardiovascular tissues, and wounds. However, the use of conventional devices with stimulating metal electrodes is invasive and requires external batteries. Consequently, electrically active materials with excellent biocompatibility have attracted attention for their applications in stimulation and regeneration in tissue engineering. To fully exploit the potential of these materials, biocompatibility, operating mechanisms, electrical properties, and even biodegradability should be carefully considered. In this review, we categorize various electrically active biomaterials based on their mechanisms for generating electrical cues, such as piezoelectric effect, triboelectric effect, and others. We also summarize the key material properties, including electrical characteristics and biodegradability, and describe their applications in tissue stimulation and regeneration for nerves, musculoskeletal tissues, and cardiovascular tissues. The electrically active biomaterials hold great potential for advancing the field of tissue engineering and their demonstrated success underscores the importance of continued research in this field.

Indexed as

Biocompatible MaterialsElectric StimulationRegenerationTissue EngineeringAnimalsHumansBiocompatible Materialsbiocompatiblebiodegradableconducting polymerelectrical stimulationpiezoelectricitytissue regenerationtissue stimulationtriboelectricity

Identifiers

PMID39806919
PMCPMC11773453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.