ArticleBMJ open2024
Accuracy of noninvasive total haemoglobin measurement for detecting anaemia in infants: a cross-sectional study in a well-child care clinic, Khon Kaen, Thailand.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07788703 (Validation of Non-invasive Spectrophotometric Haemoglobin), which is not on this map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of Non-invasive Spectrophotometric Haemoglobin (SpHb) Measurement for Detection of Anaemia and Observation of Trends in Infants Admitted to the Neonatal Intensive Care Unit (NICU): A Prospective Diagnostic Accuracy Study.
Who cites it
5 citing papers in PubMed.
- Frequency of suspected anemia in Japanese children aged 1-5 years using noninvasive hemoglobin measurement and influence of iron-fortified growing-up formula intake.BMC pediatrics · 2026Observational
- Diagnostic Performance and Trending Ability of Continuous Non-Invasive Hemoglobin Monitoring During Elective Intracranial Neurosurgery with Invasive Arterial Monitoring: Influence of Anesthetic Technique.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Prevalence and associated factors of at risk of anemia among children under five in Northeast Thailand using noninvasive hemoglobin screening in a cross sectional study.Scientific reports · 2025Article
- A Noninvasive Approach to Assess the Prevalence of and Factors Associated With Anemia Risk in Malaysian Children Under Three Years of Age: Cross-Sectional Study.JMIR pediatrics and parenting · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInfants are at a high risk of developing anaemia, which can arise from various causes, including inappropriate feeding practices. However, few infants attend anaemia screening programmes due to poor cooperation and being time-consuming. This study evaluated the accuracy of noninvasive total haemoglobin (Hb) spot-check monitoring as part of anaemia screening in healthy infants, compared with the conventional laboratory method.
designA cross-sectional study was conducted using a consecutive sampling technique.
settingThe study was carried out at the Well-Child Clinic, Khon Kaen University, Thailand.
participantsHealthy, full-term infants aged 6-12 months who were scheduled for vaccination. Spectrophotometric haemoglobin (SpHb) was measured using Masimo Rad-67 with Rainbow DCI-mini Sensor. These values were compared with conventional laboratory analysis (HbLab) performed on the same day. PRIMARY AND SECONDARY OUTCOME: Differences between Hb values using the two methods were analysed using the Bland-Altman method. Sensitivity, specificity and positive and negative predictive values (PPV and NPV) for detecting anaemia were determined. Anaemia was defined as HbLab of <11.0 g/dL.
resultsA total of 104 infants, with a median age of 9.6 (IQR 9.3, 10.9) months, were included. The prevalence of anaemia, defined by HbLab, was 38.46%. The mean SpHb was 12.20±1.10 g/dL, while the mean HbLab was 11.19±1.21 g/dL. A moderate positive correlation was observed (
conclusionA noninvasive tool for measuring Hb, with moderate sensitivity and NPV, may provide utility for initial screening to reduce unnecessary venipuncture in infants. However, its limited specificity and PPV necessitate confirmatory testing through conventional laboratory methods for accurate diagnosis. Depending on the context and available resources, it has potential to complement existing diagnostic processes, particularly in settings where rapid and noninvasive screening is prioritised. TRIAL REGISTRATION NUMBER: Thai Clinical Trials Registry (TCTR20210816002).
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