Evidence map›Paper›PMID 39806697›Full record

ArticleBMJ open2024

Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study.

Abhijit Kadam, Megha Mamulwar, Gayatri Bhambure, Shilpa Bembalkar, Shraddha Bapat, Arati Mane, Shobha Rajure, Jayanthi Mathaiyan, Nusrat Shafiq, Shankar Prinja and 14 more

Abstract read
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  5. Hospital Cost Components and Predictors inTropical medicine and infectious disease · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Abhijit Kadam *National AIDS Research Institute, Pune, Maharashtra, India.
Megha Mamulwar *National AIDS Research Institute, Pune, Maharashtra, India mmamulwar@nariindia.org.ORCID 0000-0002-9718-455X
Gayatri BhambureNational AIDS Research Institute, Pune, Maharashtra, India.ORCID 0009-0005-2946-8592
Shilpa BembalkarNational AIDS Research Institute, Pune, Maharashtra, India.ORCID 0000-0002-2491-8372
Shraddha BapatDr D Y Patil Medical College Hospital and Research Centre, Pune, Maharashtra, India.ORCID 0000-0002-7653-9921
Arati ManeNational AIDS Research Institute, Pune, Maharashtra, India.
Shobha RajureNational AIDS Research Institute, Pune, Maharashtra, India.
Jayanthi MathaiyanJawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.ORCID 0000-0002-2339-0262
Nusrat ShafiqPost Graduate Institute of Medical Education and Research, Chandigarh, India.
Shankar PrinjaPost Graduate Institute of Medical Education and Research, Chandigarh, India.ORCID 0000-0001-7719-6986
Yamunadevi RamanathanApollo Hospital, Chennai, India.ORCID 0000-0002-4403-6107
Sanjay M MehendalePD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
Vijayshri Suresh DeotaleMahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India.ORCID 0000-0002-9347-9836
Sagar KhadangaAll India Institute of Medical Science, Bhopal, Madhya Pradesh, India.
Sanjay BhattacharyaTata Medical Center, Kolkata, West Bengal, India.
Gourangie GogoiAssam Medical College and Hospital, Dibrugarh, Assam, India.ORCID 0009-0003-3903-200X
Kamini WaliaIndian Council of Medical Research, New Delhi, Delhi, India.
Samiran PandaIndian Council of Medical Research, New Delhi, Delhi, India.ORCID 0000-0002-5077-6275
Raman GangakhedkarFaculty of Medical and Health Sciences, Symbiosis International (Deemed University), Pune, Manaharashtra, India.
Ruchita AttalMahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India.
Jharna MandalJawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Venkateswaran RamanathanJawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.ORCID 0000-0002-1602-5785
Pallab RayPost Graduate Institute of Medical Education and Research, Chandigarh, India.
Susmita ChatterjeeThe George Institute for Global Health India, New Delhi, Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treating antimicrobial-resistant pathogens in India.

methodsThis cohort study was conducted in eight hospitals including government (GH), private (PH) and trust hospitals (TH), considering their ownership, geographical location and categories of cities. This study had a retrospective component, which calculated the direct cost of treating resistant and susceptible blood stream infections caused by selected WHO priority pathogens. The prospective component estimated indirect cost and financial coping strategies for the treatment of AMR. In the retrospective component, 1723 records were included and 170 patients were recruited in the prospective component.

resultsThe median total cost for management of antimicrobial-resistant infections was US$199 (IQR 89, 377) as opposed to US$109 (IQR 55, 229) for susceptible infection in GH. Our study has revealed that the ICs for

conclusionsThe current study concluded that the presence of any critical or high priority pathogens led to an increase in the direct and indirect medical costs. The IC varied with hospital type, length of stay, pathogen, comorbidities and diagnosis. Prospective studies are needed for precise understanding of variations in the costs of treating AMR infections.

Indexed as

Anti-Bacterial AgentsBacterial InfectionsDrug Resistance, BacterialHealth Care CostsHospitalizationAdultCohort StudiesFemaleHumansIndiaMaleMiddle AgedProspective StudiesRetrospective StudiesAnti-Bacterial AgentsDecision MakingEPIDEMIOLOGYHEALTH ECONOMICS

Identifiers

PMID39806697
PMCPMC11664386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.