Observational studyBMJ open2024
Treating shock with norepinephrine administered in midline catheters in an intermediary care unit: a retrospective cohort study.
Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06121115 (Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit - a Retrospective Study of Complications and Patient Outcomes), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit - a Retrospective Study of Complications and Patient Outcomes
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Central venous versus short midline catheter in difficult intravenous access patients: a randomised clinical pilot trial.BMJ open · 2026Trial
- Utility of a Peripheral Intravenous Catheter for Administration of Vasopressors: A Narrative Review.Cureus · 2026Review
- Extravasation, thrombosis, and infection with vasopressor infusion through peripheral intravenous catheters: a systematic review and meta-analysis.Cardiovascular diagnosis and therapy · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA rising incidence of septic shock as well as recommendations for early vasopressor initiation has increased the number of patients eligible for norepinephrine (NE). Traditionally, NE has been administered through central lines, in intensive care units, due to the risk of extravasation in peripheral lines. The aim of the current study is to determine the rate of complications and patient outcomes when NE is administered through midline catheters (MCs) in intermediary care units (IMCUs).
designRetrospective cohort study.
settingThree IMCUs in southern Sweden
participantsPatients with septic shock who received NE through a MC from September 2020 through March 2023. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was a major complication to treatment, defined as extravasation of NE, catheter-associated venous thromboembolism and catheter-associated bloodstream infection (BSI). Secondary outcomes included patient outcomes after intermediary care (either deceased, discharged to regular ward care or intensive care) and the need for additional central lines.
resultsOf 474 eligible patients, 472 were included, with a median (IQR) age of 73.5 (65-80) years, with 281 (60%) men. The median (IQR) duration of NE infusion was 21 (9-38) hours, with a median (IQR) dosage of 0.12 (0.08-0.20) µg/kg/min. Major complications occurred in 12 cases (2.5%), with one suspected extravasation, seven thromboembolic events and four catheter-related BSIs. After intermediary care, 334 patients (71%) were discharged to regular ward care, 66 patients (14%) were escalated to intensive care and 72 (15%) died in intermediary care, of whom 69 had a documented ceiling of care decision. 100 patients (21%) received a central line.
conclusionNE administration in MCs was associated with a low rate of short-term complications and could decrease the need for central lines. MCs can enable the initial management of circulatory failure outside intensive care, but more studies are needed to determine the long-term value of IMCUs. TRIAL REGISTRATION NUMBER: NCT06121115.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.