Evidence map›Paper›PMID 39806419›Full record

ReviewJournal of translational medicine2025

tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer.

Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. The Roles of tRNA-Derived Fragments in Cancer: Updates and Perspectives.International journal of molecular sciences · 2025
    Review
  11. Small RNAs as therapeutic agents: From catalytic motifs to regulatory pathways.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  12. Review
  13. A primer on tRNAs, tRNA-mFrontiers in cell and developmental biology · 2025
    Review
  14. Article
  15. Hypoxia-induced tRF-3Frontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bo ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.
Yanru PanHealth Science Center, Ningbo University, Ningbo, 315211, China.
Zhe LiDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China. fylizhe@nbu.edu.cn.
Kefeng HuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China. fyhukefeng@nbu.edu.cn.ORCID 0000-0002-5546-5230

Funding

Medical Science and Technology Project of Zhejiang Province 2023RC262Medical Science and Technology Project of Zhejiang Province 2024KY1491Ningbo Leading Medical & Healthy Discipline 2022-S04
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age of onset. In recent years, there has been increasing recognition of the significance of tRNA-derived small RNAs (tsRNAs), encompassing tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs). Their involvement in regulating translation, gene expression, reverse transcription, and epigenetics has gradually come to light. Emerging research has revealed dysregulation of tsRNAs in CRC, implicating their role in CRC initiation and progression, and highlighting their potential in early diagnosis, prognosis, and therapeutic strategies. Although the clinical application of tsRNAs is still in its early stages, recent findings highlight a close relationship between the biogenesis and function of tsRNAs, tRNA chemical modifications, and the tumor immune microenvironment (TIME). Additionally, similar to other small RNAs, tsRNAs can be effectively delivered via nanoparticles (NPs). Consequently, future research should focus on elucidating the clinical significance of tsRNAs concerning base modifications, TIME regulation, cancer immunotherapy, and NPs delivery systems to facilitate their clinical translation.

Indexed as

Biomarkers, TumorColorectal NeoplasmsRNA, Small UntranslatedRNA, TransferAnimalsGene Expression Regulation, NeoplasticHumansBiomarkers, TumorRNA, Small UntranslatedRNA, TransferBiological behaviorBiomarkerClinical applicationColorectal cancerTherapeutic strategiestRNA-derived small RNAs

Identifiers

PMID39806419
PMCPMC11727791

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.